Goat anti-RARA Antibody | MyBioSource MBS421389 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-RARA Antibody

catalog :

MBS421389

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421389

products type :

Antibody

products full name :

Goat anti-RARA Antibody

products short name :

RARA

products name syn :

RARA; RAR; NR1B1; retinoic acid receptor, alpha; Retinoic acid receptor, alpha polypeptide; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR short form; RARA antibody; RAR antibody; NR1B1 antibody; retinoic acid receptor; alpha antibody; Retinoic acid receptor; alpha polypeptide antibody; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form antibody; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR short form antibody

other names :

retinoic acid receptor alpha isoform 1; Retinoic acid receptor alpha; retinoic acid receptor alpha; retinoic acid receptor alpha; Nuclear receptor subfamily 1 group B member 1

products gene name :

RARA

other gene names :

RARA; RARA; RAR; NR1B1; NR1B1; RAR-alpha

uniprot entry name :

RARA_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

462

sequence :

SPSLSPSSHRSSPATQSP

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: In paraffin embedded Human Cerebellum shows staining of Purkinje cytoplasm. Recommended concentration, 4-6ug/ml. Western Blot: Approx 50kDa band observed in Human Brain (Cerebellum and Hippocampus) lysates (calculated MW of 50.8kDa according to NP_000955.1; NP_001019980.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-SPSLSPSSHRSSPATQSP, from the C Terminus of the protein sequence according to NP_000955.1; NP_001138773.1; NP_001019980.1; NP_001138774.1. Epitope: C Terminus

other info2 :

Note: NP_000955.1 (isfa) and NP_001138773.1(alpha) represent identical proteins. This antibody is expected to recognize all three reported isoforms (NP_000955.1; NP_001019980.1; NP_001138774.1). Please note the epitope is from the mouse/rat sequence. Human sequence is SPSLSPSSNRSSPATHSP and thus highly similar.

ncbi gi num :

4506419

ncbi acc num :

NP_000955.1

ncbi gb acc num :

NM_000964.3

ncbi mol weight :

39,700 Da

ncbi pathways :

Activation Of HOX Genes During Differentiation Pathway (1339139); Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway (1339140); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipogenesis Pathway (198832); Developmental Biology Pathway (1270302); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); IL-3 Signaling Pathway (198881); Integrated Pancreatic Cancer Pathway (711360)

ncbi summary :

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

uniprot summary :

RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor; Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: actin cytoskeleton; cell soma; cell surface; cytoplasm; dendrite; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm. Molecular Function: alpha-actinin binding; chromatin DNA binding; drug binding; enzyme binding; histone deacetylase binding; mRNA 5'-UTR binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor binding; retinoic acid binding; retinoic acid receptor activity; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription factor binding; translation repressor activity, nucleic acid binding; zinc ion binding. Biological Process: apoptotic cell clearance; embryonic camera-type eye development; female pregnancy; germ cell development; glandular epithelial cell development; hippocampus development; limb development; liver development; multicellular organism growth; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translational initiation; negative regulation of tumor necrosis factor production; neural tube closure; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein amino acid phosphorylation; regulation of myelination; regulation of synaptic plasticity; response to cytokine stimulus; response to estradiol stimulus; response to ethanol; response to retinoic acid; response to vitamin A; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; signal transduction; spermatogenesis; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation. Disease: Acute Promyelocytic Leukemia

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage