antibody

Goat anti-ORC3L Antibody

MBS421369

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-ORC3L Antibody

ORC3L

ORC3L; origin recognition complex, subunit 3-like (yeast); LAT; ORC3; LATHEO; IMAGE50150; origin recognition complex, subunit 3 (yeast homolog)-like; OTTHUMP00000040611; homolog of latheo, Drosophila; RP3-486L4.1; origin recognition complex, subunit 3; ORC3L antibody; origin recognition complex; subunit 3-like (yeast) antibody; LAT antibody; ORC3 antibody; LATHEO antibody; IMAGE50150 antibody; origin recognition complex; subunit 3 (yeast homolog)-like antibody; OTTHUMP00000040611 antibody; homolog of latheo; Drosophila antibody; RP3-486L4.1 antibody; origin recognition complex; subunit 3 antibody

origin recognition complex subunit 3 isoform 1; Origin recognition complex subunit 3; origin recognition complex subunit 3; origin recognition complex subunit 3; Origin recognition complex subunit Latheo

ORC3L

ORC3; ORC3; LAT; ORC3L; LATHEO; LATHEO; ORC3L

ORC3_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

712

QKTDHVARLTWGGC

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000.

Immunogen: Peptide with sequence QKTDHVARLTWGGC, from the C Terminus of the protein sequence according to NP_862820.1; NP_036513.2. Epitope: C Terminus

Note: This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_036513.2).

32483369

NP_862820.1

NM_181837.2

65,929 Da

Activation Of ATR In Response To Replication Stress Pathway (1269757); Activation Of The Pre-replicative Complex Pathway (1269773); Assembly Of The ORC Complex At The Origin Of Replication Pathway (1269834); Assembly Of The Pre-replicative Complex Pathway (1269833); Association Of Licensing Factors With The Pre-replicative Complex Pathway (1269795); CDC6 Association With The ORC:origin Complex Pathway (1269835); CDT1 Association With The CDC6:ORC:origin Complex Pathway (1269836); Cell Cycle Pathway (1269741); Cell Cycle Checkpoints Pathway (1269742); Cell Cycle, Mitotic Pathway (1269763)

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

ORC3L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC3 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 6q14.3-q16.1. Cellular Component: nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; origin recognition complex. Molecular Function: DNA replication origin binding; protein binding. Biological Process: DNA replication; G1/S transition of mitotic cell cycle

0.1 mg

300 USD