Goat anti-PDIA3/ERp57/GRP58 Antibody | MyBioSource MBS421355 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-PDIA3/ERp57/GRP58 Antibody

catalog :

MBS421355

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421355

products type :

Antibody

products full name :

Goat anti-PDIA3/ERp57/GRP58 Antibody

products short name :

PDIA3/ERp57/GRP58

products name syn :

PDIA3; GRP58; ERp57; protein disulfide isomerase family A, member 3; ERp60; ERp61; GRP57; HsT17083; P58; PI-PLC; 58 kDa microsomal protein; endoplasmic reticulum P58; glucose regulated protein, 58kDa; phospholipase C-alpha; protein disulfide isomerase-ass; PDIA3 antibody; GRP58 antibody; ERp57 antibody; protein disulfide isomerase family A; member 3 antibody; ERp60 antibody; ERp61 antibody; GRP57 antibody; HsT17083 antibody; P58 antibody; PI-PLC antibody; 58 kDa microsomal protein antibody; endoplasmic reticulum P58 antibody; glucose regulated protein; 58kDa antibody; phospholipase C-alpha antibody; protein disulfide isomerase-associated 3 antibody; ER60 antibody; protein disulfide-isomerase A3 antibody; PDIA3 / ERp57 / GRP58

other names :

protein disulfide-isomerase A3; Protein disulfide-isomerase A3; protein disulfide-isomerase A3; protein disulfide isomerase family A member 3; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60

products gene name :

PDIA3

products gene name syn :

ERp57; GRP58

other gene names :

PDIA3; PDIA3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n; ERP57; ERP60; GRP58; p58; ER protein 57; ERp57; ER protein 60; ERp60

uniprot entry name :

PDIA3_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Cow

sequence length :

505

sequence :

EEKPKKKKKAQEDL

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 55kDa band observed in lysates of cell lines HepG2 and NIH3T3 (calculated MW of 56.8kDa according to NP_005304.3). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-EEKPKKKKKAQEDL, from the C Terminus of the protein sequence according to NP_005304.3. Epitope: C Terminus

ncbi gi num :

21361657

ncbi acc num :

NP_005304.3

ncbi gb acc num :

NM_005313.4

ncbi mol weight :

56,782 Da

ncbi pathways :

Adaptive Immune System Pathway (1269171); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Asparagine N-linked Glycosylation Pathway (1268714); Calnexin/calreticulin Cycle Pathway (1268723); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); ER-Phagosome Pathway (1269197); Immune System Pathway (1269170)

ncbi summary :

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

uniprot summary :

GRP58: a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway. Protein type: EC 5.3.4.1; Chaperone; Apoptosis; Protease; Isomerase; Endoplasmic reticulum; Phospholipase. Chromosomal Location of Human Ortholog: 15q15. Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; myelin sheath; nucleus. Molecular Function: cysteine-type endopeptidase activity; disulfide oxidoreductase activity; phospholipase C activity; protein binding; protein disulfide isomerase activity. Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cell redox homeostasis; protein folding; protein import into nucleus; protein retention in ER; proteolysis; signal transduction

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage