catalog number :
MBS421351
products full name :
Goat anti-SLC6A4 / 5HTT / SERT Antibody
products short name :
SLC6A4/5HTT/SERT
products name syn :
SLC6A4; SERT; solute carrier family 6 (neurotransmitter transporter; serotonin); member 4; HGNC:11050; 5-HTT; HTT; OCD1; hSERT; 5-hydroxytryptamine transporter; 5HT transporter; Na+/Cl- dependent serotonin transporter; serotonin transporter; sodium-dependent serotonin transporter; solute carrier family 6 member 4; 5-HTTLPR; OTTHUMP00000163633; Goat Anti-SLC6A4 (aa605-618); SLC6A4; SERT; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; HGNC:11050; 5-HTT; HTT; OCD1; hSERT; 5-hydroxytryptamine transporter; 5HT transporter; Na+/Cl- dependent serotonin transporter; serotonin transporter; sodium-dependent serotonin transporter; solute carrier family 6 member 4; 5-HTTLPR; OTTHUMP00000163633
other names :
sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter; sodium-dependent serotonin transporter; 5HT transporter; serotonin transporter 1; Na+/Cl- dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6 (neurotransmitter transporter), member 4; 5HT transporter; 5HTT; Solute carrier family 6 member 4
products gene name :
SLC6A4
other gene names :
SLC6A4; SLC6A4; HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR; HTT; SERT; 5HTT
uniprot entry name :
SC6A4_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
app notes :
Western Blot: Approx 70kDa band observed in Human Colon and Duodenum lysates (calculated MW of 70.3kDa according to NP_001036.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000. Immunocytochemistry: Anonymous customer used this antibody successfully in ICC on PC12 when used at 5ug/ml o/n at 4C.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-LHQGERETWGK, from the internal region of the protein sequence according to NP_001036.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS428215
ncbi acc num :
NP_001036.1
ncbi gb acc num :
NM_001045.5
ncbi mol weight :
74,979 Da
ncbi pathways :
Monoamine Transport Pathway 198851!!SIDS Susceptibility Pathways 198901!!Serotonergic Synapse Pathway 525336!!Serotonin Transporter Activity Pathway 920962!!Synaptic Vesicle Pathway 672457
ncbi summary :
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]