Goat anti-TIM3/HAVCR2 Antibody | MyBioSource MBS421344 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TIM3/HAVCR2 Antibody

catalog :

MBS421344

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421344

products type :

Antibody

products full name :

Goat anti-TIM3/HAVCR2 Antibody

products short name :

TIM3/HAVCR2

products name syn :

HAVCR2; TIM3; hepatitis A virus cellular receptor 2; FLJ14428; KIM-3; TIMD3; Tim-3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; kidney injury molecule-3; HAVCR2 antibody; TIM3 antibody; hepatitis A virus cellular receptor 2 antibody; FLJ14428 antibody; KIM-3 antibody; TIMD3 antibody; Tim-3 antibody; T cell immunoglobulin mucin 3 antibody; T cell immunoglobulin mucin-3 antibody; kidney injury molecule-3 antibody; TIM3 / HAVCR2

other names :

hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3

products gene name :

HAVCR2

products gene name syn :

TIM3

other gene names :

HAVCR2; HAVCR2; TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3

uniprot entry name :

HAVR2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Dog

sequence length :

301

sequence :

KWYSHSKEKIQN

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 35kDa band observed in Human Tonsil, Thymus, Lymph Node and Spleen lysates (calculated MW of 33.4kDa according to NP_116171.3). In transfected HEK293 transiently expressing HAVCR2 a band of approx.35kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.3-1. 0ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KWYSHSKEKIQN, from the internal region of the protein sequence according to NP_116171.3. Epitope: Internal region

ncbi gi num :

49574534

ncbi acc num :

NP_116171.3

ncbi gb acc num :

NM_032782.4

ncbi mol weight :

16,149 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Immune System Pathway (1269170); Interleukin-2 Signaling Pathway (1269321); Signaling By Interleukins Pathway (1269318)

ncbi summary :

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

uniprot summary :

TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q33.3. Cellular Component: cell junction; cell surface; early endosome; immunological synapse; integral to membrane. Molecular Function: metal ion binding. Biological Process: adaptive immune response; defense response to Gram-positive bacterium; inflammatory response; inhibition of NF-kappaB transcription factor; innate immune response; macrophage activation during immune response; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of interferon-alpha production; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of interleukin-6 production; negative regulation of myeloid dendritic cell activation; negative regulation of natural killer cell activation; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of T cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation; positive regulation of T cell proliferation; regulation of tolerance induction dependent upon immune response; toll-like receptor 3 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway. Disease: Rheumatoid Arthritis

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage