Goat anti-DPP4/CD26 Antibody | MyBioSource MBS421335 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-DPP4/CD26 Antibody

catalog :

MBS421335

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421335

products type :

Antibody

products full name :

Goat anti-DPP4/CD26 Antibody

products short name :

DPP4/CD26

products name syn :

DPP4; CD26; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); ADABP; ADCP2; DPPIV; TP103; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing prote; DPP4 antibody; CD26 antibody; dipeptidyl-peptidase 4 (CD26; adenosine deaminase complexing protein 2) antibody; ADABP antibody; ADCP2 antibody; DPPIV antibody; TP103 antibody; T-cell activation antigen CD26 antibody; adenosine deaminase complexing protein 2 antibody; dipeptidylpeptidase 4 (CD26; adenosine deaminase complexing protein 2) antibody; dipeptidylpeptidase IV antibody; dipeptidylpeptidase IV (CD26; adenosine deaminase complexing protein 2) antibody; DPP4 / CD26

other names :

dipeptidyl peptidase 4; Dipeptidyl peptidase 4; dipeptidyl peptidase 4; dipeptidyl peptidase 4; ADABP; Adenosine deaminase complexing protein 2; ADCP-2

products gene name :

DPP4

products gene name syn :

CD26

other gene names :

DPP4; DPP4; CD26; ADABP; ADCP2; DPPIV; TP103; ADCP2; CD26; ADCP-2; DPP IV

uniprot entry name :

DPP4_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

766

sequence :

PPHFDKSKKYP

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 110kDa band observed in Rat Lung lysates (calculated MW of 88.3Da according to NP_001926.2). The observed molecular weight of this glycoprotein corresponds to earlier findings in literature with different antibodies (Herrera et al, J Biol Chem.2001 Jun 1;276(22): 19532-9.; PMID: 11278278). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-PPHFDKSKKYP, from the internal region of the protein sequence according to NP_001926.2. Epitope: Internal region

ncbi gi num :

18765694

ncbi acc num :

NP_001926.2

ncbi gb acc num :

NM_001935.3

ncbi mol weight :

88,279 Da

ncbi pathways :

Incretin Synthesis, Secretion, And Inactivation Pathway (1268750); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868); Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway (1268751); Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway (1268752)

ncbi summary :

The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

uniprot summary :

DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily. Protein type: Cell surface; Membrane protein, integral; EC 3.4.14.5; Protease; Cell adhesion. Chromosomal Location of Human Ortholog: 2q24.3. Cellular Component: apical plasma membrane; cell surface; endocytic vesicle; focal adhesion; integral to membrane; intercellular canaliculus; lamellipodium; lipid raft; lysosomal membrane; membrane; plasma membrane. Molecular Function: dipeptidyl-peptidase activity; identical protein binding; protease binding; protein binding; protein homodimerization activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity; viral receptor activity. Biological Process: behavioral fear response; endothelial cell migration; entry of virus into host cell; positive regulation of cell proliferation; proteolysis; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; T cell activation; T cell costimulation

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage