Goat anti-Glutathione Peroxidase 1 (isoform1) Antibody | MyBioSource MBS421332 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Glutathione Peroxidase 1 (isoform1) Antibody

catalog :

MBS421332

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

HRP

reactivity :

human

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421332

products type :

Antibody

products full name :

Goat anti-Glutathione Peroxidase 1 (isoform1) Antibody

products short name :

Glutathione Peroxidase 1

products name syn :

glutathione peroxidase 1; HGNC: 4553; GPX1; GSHPX1; MGC14399; MGC88245; glutathione peroxidase 1 antibody; HGNC: 4553 antibody; GPX1 antibody; GSHPX1 antibody; MGC14399 antibody; MGC88245 antibody; Glutathione Peroxidase 1; Glutathione Peroxidase 1 (isoform1)

other names :

glutathione peroxidase 1 isoform 1; Glutathione peroxidase 1; glutathione peroxidase 1; glutathione peroxidase 1; Cellular glutathione peroxidase

products gene name :

GPX1

other gene names :

GPX1; GPX1; GPXD; GSHPX1; GPx-1; GSHPx-1

uniprot entry name :

GPX1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Pig; Expected from sequence similarity: Human

sequence length :

203

sequence :

REALPAPSDDATA

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Cerebral Cortex shows staining of microglia. Recommended concentration, 3-5ug/ml. Frozen sections of Porcin Kidney shows staining of cytoplasm in PCT epithelial cells. Recommended concentration, 20ug/ml. Western Blot: Approx 22kDa band observed in Human Liver and Kidney lysates (calculated MW of 22.1kDa according to NP_000572.2). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-REALPAPSDDATA, from the internal region of the protein sequence according to NP_000572.2. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise isoform 1 (NP_000572.2) only.

ncbi gi num :

41406084

ncbi acc num :

NP_000572.2

ncbi gb acc num :

NM_000581.2

ncbi mol weight :

10,289 Da

ncbi pathways :

Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (1270087); Arachidonic Acid Metabolism Pathway (366); Cellular Responses To Stress Pathway (1270414); Detoxification Of Reactive Oxygen Species Pathway (1270420); Direct P53 Effectors Pathway (137939); Folate Metabolism Pathway (198833)

ncbi summary :

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Protein type: EC 1.11.1.9; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion. Molecular Function: glutathione peroxidase activity; SH3 domain binding. Biological Process: angiogenesis involved in wound healing; blood vessel endothelial cell migration; cell redox homeostasis; endothelial cell development; fat cell differentiation; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; induction of apoptosis by oxidative stress; interaction with symbiont; lipoxygenase pathway; myoblast proliferation; negative regulation of caspase activity; negative regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; protein amino acid oxidation; purine nucleotide catabolic process; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; regulation of neuron apoptosis; response to gamma radiation; response to hydrogen peroxide; response to hydroperoxide; response to reactive oxygen species; response to selenium ion; response to symbiotic bacterium; response to xenobiotic stimulus; sensory perception of sound; skeletal muscle fiber development; skeletal muscle regeneration; thermoregulation; triacylglycerol metabolic process; UV protection; vasodilation. Disease: Glutathione Peroxidase Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage