Goat anti-VMAT2/SLC18A2 Antibody | MyBioSource MBS421308 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-VMAT2/SLC18A2 Antibody

catalog :

MBS421308

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421308

products type :

Antibody

products full name :

Goat anti-VMAT2/SLC18A2 Antibody

products short name :

VMAT2/SLC18A2

products name syn :

SLC18A2; VMAT2; SVAT; SVMT; VAT2; solute carrier family 18 (vesicular monoamine), member 2; MGC120477; MGC120478; MGC26538; VMAT2 antibody; SLC18A2 antibody; SVAT antibody; SVMT antibody; VAT2 antibody; solute carrier family 18 (vesicular monoamine); member 2 antibody; VMAT2 / SLC18A2

other names :

synaptic vesicular amine transporter; Synaptic vesicular amine transporter; synaptic vesicular amine transporter; solute carrier family 18 member A2; Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2

products gene name :

SLC18A2

products gene name syn :

VMAT2

other gene names :

SLC18A2; SLC18A2; SVAT; SVMT; VAT2; VMAT2; SVMT; VMAT2; VAT2

uniprot entry name :

VMAT2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

514

sequence :

SYPIGEDEESESD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 55kDa band observed in Human Placenta, Uterus, Adrenal Gland and Pancrease lysates (calculated MW of 55.7kDa according to NP_003045.2). Recommended concentration 1-3ug/ml

other info1 :

Immunogen: Peptide with sequence C-SYPIGEDEESESD, from the C Terminus of the protein sequence according to NP_003045.2. Epitope: C Terminus

ncbi gi num :

42476325

ncbi acc num :

NP_003045.2

ncbi gb acc num :

NM_003054.4

ncbi mol weight :

22,980 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Cocaine Addiction Pathway (546258); Cocaine Addiction Pathway (546273); Dopamine Neurotransmitter Release Cycle Pathway (1268772); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (1269934)

ncbi summary :

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

uniprot summary :

SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family. Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 10q25. Cellular Component: cell soma; integral to plasma membrane; membrane; plasma membrane; synaptic vesicle; synaptic vesicle membrane; terminal button. Molecular Function: amine transmembrane transporter activity; drug binding; enzyme binding; heat shock protein binding; monoamine transmembrane transporter activity; serotonin transmembrane transporter activity. Biological Process: aging; dopamine transport; endocytic recycling; glucose homeostasis; insulin secretion; locomotory behavior; monoamine transport; negative regulation of neurotransmitter transport; neurotransmitter secretion; post-embryonic development; response to amphetamine; response to cocaine; response to corticosterone stimulus; response to herbicide; response to starvation; response to zinc ion; sequestering of neurotransmitter; serotonin transport; synaptic transmission; synaptic vesicle amine transport; transmembrane transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage