catalog number :
MBS421307
products full name :
Goat anti-collagen type XI alpha 2 Antibody
products short name :
collagen type XI alpha 2
products name syn :
COL11A2; collagen; type XI; alpha 2; DAQB-79P13.8; HGNC:2187; DFNA13; HKE5; PARP; STL3; Collagen alpha 2(XI); COL11A2; collagen, type XI, alpha 2; DAQB-79P13.8; HGNC:2187; DFNA13; HKE5; PARP; STL3; Collagen alpha 2(XI)
other names :
collagen alpha-2(XI) chain isoform 1 preproprotein; Collagen alpha-2(XI) chain; collagen alpha-2(XI) chain; collagen alpha-2(XI) chain; pro-a2 chain of collagen type XI; collagen, type XI, alpha 2
products gene name :
COL11A2
other gene names :
COL11A2; COL11A2; HKE5; PARP; STL3; FBCG2; DFNA13; DFNB53
uniprot entry name :
COBA2_HUMAN
reactivity :
Human, Dog, Pig, Cow
sequence :
QKELECEGGQRERPQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments in human brain and bone marrow lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Peptide ELISA: antibody detection limit dilution 1:1000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence QKELECEGGQRERPQ, from the internal region of the protein sequence according to NP_542411.2; NP_542412.2; NP_542410.2; NP_001157243.1. Corresponding Immunizing Peptide: Catalog #MBS426163
other info2 :
Important Note: This antibody is expected to recognise all four reported isoforms (NP_542411.2; NP_542412.2; NP_542410.2; NP_001157243.1).
ncbi acc num :
NP_542411.2
ncbi gb acc num :
NM_080680.2
ncbi mol weight :
31,960 Da
ncbi pathways :
Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Collagen Biosynthesis And Modifying Enzymes Pathway 645289!!Collagen Formation Pathway 645288!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Extracellular Matrix Organization Pathway 576262!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067
ncbi summary :
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009]