Goat anti-Leptin Receptor Antibody | MyBioSource MBS421306 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Leptin Receptor Antibody

catalog :

MBS421306

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421306

products type :

Antibody

products full name :

Goat anti-Leptin Receptor Antibody

products short name :

Leptin Receptor

products name syn :

LEPR; leptin receptor; CD295; OBR; OB receptor; LeprB; LEPR antibody; leptin receptor antibody; CD295 antibody; OBR antibody; OB receptor antibody; LeprB antibody; Leptin Receptor; Leptin Receptor

other names :

leptin receptor isoform 1; Leptin receptor; leptin receptor; leptin receptor; HuB219; OB receptor; OB-R; CD_antigen: CD295

products gene name :

LEPR

other gene names :

LEPR; LEPR; OBR; OB-R; CD295; LEP-R; LEPRD; DB; OBR; LEP-R; OB-R

uniprot entry name :

LEPR_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Dog

sequence length :

1165

sequence :

TQDDIEKHQSDAG

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 150kDa band observed in Human Brain lysates (calculated MW of 132kDa according to NP_002294.2). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-TQDDIEKHQSDAG, from the internal region of the protein sequence according to NP_002294.2; NP_001003679.1; NP_001003680.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1).

ncbi gi num :

40254464

ncbi acc num :

NP_002294.2

ncbi gb acc num :

NM_002303.5

ncbi mol weight :

96,042 Da

ncbi pathways :

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Leptin Signaling Pathway (672456)

ncbi summary :

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

uniprot summary :

LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p31. Cellular Component: basolateral plasma membrane; extracellular region; integral to membrane; plasma membrane; receptor complex. Molecular Function: identical protein binding; protein binding; transmembrane receptor activity. Biological Process: angiogenesis; cell surface receptor linked signal transduction; cholesterol metabolic process; energy reserve metabolic process; glucose homeostasis; leptin-mediated signaling pathway; multicellular organismal development; negative regulation of autophagy; negative regulation of gluconeogenesis; negative regulation of hydrolase activity; regulation of bone remodeling; sexual reproduction; T cell differentiation. Disease: Leptin Receptor Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage