Goat anti-Monoamine Oxidase A Antibody | MyBioSource MBS421298 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Monoamine Oxidase A Antibody

catalog :

MBS421298

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421298

products type :

Antibody

products full name :

Goat anti-Monoamine Oxidase A Antibody

products short name :

Monoamine Oxidase A

products name syn :

MAOA; monoamine oxidase A; HGNC: 6833; RP1-201D17__B.2; monoamine oxidase A antibody; HGNC: 6833 antibody; MAOA antibody; RP1-201D17__B.2 antibody; Monoamine Oxidase A; Monoamine Oxidase A

other names :

amine oxidase; Amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase A; Monoamine oxidase type A; MAO-A

products gene name :

MAOA

other gene names :

MAOA; MAOA; MAO-A; MAO-A

uniprot entry name :

AOFA_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

527

sequence :

DAPWEAQHADKWDK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 70kDa band observed in Human Heart lysates o(calculated MW of 60. 0kDa according to NP_000231.1). In transfected HEK293 transiently expressing MAOA a band of approx. 60 kDa is observed. This band is not observed in the non-transfected HEK293. The user is warned for non-specific background in Western blot. Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-DAPWEAQHADKWDK, from the internal region of the protein sequence according to NP_000231.1. Epitope: Internal region

ncbi gi num :

4557735

ncbi acc num :

NP_000231.1

ncbi gb acc num :

NM_000240.3

ncbi mol weight :

44,848 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amine Oxidase Reactions Pathway (1270203); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biogenic Amine Synthesis Pathway (198793); Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway (1270204); Biological Oxidations Pathway (1270189)

ncbi summary :

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

uniprot summary :

MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. Protein type: EC 1.4.3.4; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - arginine and proline; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450. Chromosomal Location of Human Ortholog: Xp11.3. Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion. Molecular Function: amine oxidase activity; FAD binding; serotonin binding. Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; neurotransmitter metabolic process; phenylethylamine metabolic process; serotonin metabolic process. Disease: Brunner Syndrome

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage