Goat anti-SRD5A2/5-alpha reductase 2 Antibody | MyBioSource MBS421271 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-SRD5A2/5-alpha reductase 2 Antibody

catalog :

MBS421271

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421271

products type :

Antibody

products full name :

Goat anti-SRD5A2/5-alpha reductase 2 Antibody

products short name :

SRD5A2/5-alpha reductase 2

products name syn :

Goat Anti-SRD5A2 Antibody; SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); steroid 5-alpha-reductase 2; MGC138457; 3-oxo-5 alpha-steroid 4-dehydrogenase 2; SRD5A2 antibody; steroid-5-alpha-reductase; alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody; steroid 5-alpha-reductase 2 antibody; MGC138457 antibody; 3-oxo-5 alpha-steroid 4-dehydrogenase 2 antibody; 5-alpha reductase 2; SRD5A2 / 5-alpha reductase 2

other names :

3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; steroid 5 alpha-reductase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase

products gene name :

SRD5A2

other gene names :

SRD5A2; SRD5A2; S5AR 2

uniprot entry name :

S5A2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

254

sequence :

QVQCQQSPVLAG

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: (0.3ug/ml) staining of Human Prostate lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

other info1 :

Immunogen: Peptide with sequence QVQCQQSPVLAG, from the N Terminus of the protein sequence according to NP_000339.2. Epitope: N Terminus

ncbi gi num :

39812447

ncbi acc num :

NP_000339.2

ncbi gb acc num :

NM_000348.3

ncbi mol weight :

28,393 Da

ncbi pathways :

Androgen Biosynthesis Pathway (1270050); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Steroid Hormones Pathway (1270046); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Steroid Hormone Biosynthesis Pathway (82940); Steroid Hormone Biosynthesis Pathway (301); Allopregnanolone Biosynthesis Pathway (1108771); Allopregnanolone Biosynthesis Pathway (1108836)

ncbi summary :

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]

uniprot summary :

SRD5A2: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH). A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Belongs to the steroid 5-alpha reductase family. Protein type: EC 1.3.1.22; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane. Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; sterol 5-alpha reductase activity. Biological Process: androgen biosynthetic process; androgen metabolic process; biphenyl metabolic process; cell differentiation; cell-cell signaling; dibenzo-p-dioxin metabolic process; female genitalia development; hippocampus development; hypothalamus development; male genitalia development; male gonad development; phthalate metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to nutrient levels; response to peptide hormone stimulus; response to testosterone stimulus; steroid catabolic process. Disease: Pseudovaginal Perineoscrotal Hypospadias

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage