catalog number :
MBS421233
products full name :
Goat anti-FOXP2 (C terminus) Antibody
products short name :
FOXP2
products name syn :
FOXP2; forkhead box P2; SPCH1; CAGH44; TNRC10; CAG repeat protein 44; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; DKFZp686H1726; OTTHUMP00000196932; Goat Anti-FOXP2 (internal); FOXP2; forkhead box P2; SPCH1; CAGH44; TNRC10; CAG repeat protein 44; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; DKFZp686H1726; OTTHUMP00000196932
other names :
forkhead box protein P2 isoform I; Forkhead box protein P2; forkhead box protein P2; CAG repeat protein 44; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; trinucleotide repeat-containing gene 10 protein; forkhead box P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
products gene name :
FOXP2
other gene names :
FOXP2; FOXP2; SPCH1; CAGH44; TNRC10; CAGH44; TNRC10
uniprot entry name :
FOXP2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow etc
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: An anonymous customer found positive results in IHC on Mouse embryonic spinal cord. Western Blot: Approx 80kDa band observed in human brain (cerebellum) lysates (calculated MW of 79.9kDa according to NP_055306.1). Recommended concentration: 0.5-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-REIEEEPLSEDLE, from the C Terminus of the protein sequence according to NP_055306.1; NP_683696.2; NP_683697.1. Corresponding Immunizing Peptide: Catalog #MBS428462
other info2 :
Important Note: This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1).
ncbi acc num :
NP_055306.1
ncbi gb acc num :
NM_014491.3
ncbi mol weight :
81,840 Da
ncbi summary :
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]