catalog number :
MBS421218
products full name :
Goat anti-Spleen tyrosine kinase / SYK Antibody
products short name :
Spleen tyrosine kinase/SYK
products name syn :
SYK; spleen tyrosine kinase; HGNC:11491; DKFZp313N1010; FLJ25043; FLJ37489; OTTHUMP00000021628; OTTHUMP00000021629; SYK; spleen tyrosine kinase; HGNC:11491; DKFZp313N1010; FLJ25043; FLJ37489; OTTHUMP00000021628; OTTHUMP00000021629
other names :
tyrosine-protein kinase SYK isoform Syk(L); Tyrosine-protein kinase SYK; tyrosine-protein kinase SYK; spleen tyrosine kinase; Spleen tyrosine kinase; p72-Syk
other gene names :
SYK; SYK; p72-Syk
uniprot entry name :
KSYK_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 70kDa band observed in Human Bone marrow, Lymph Node, and Spleen lysates (calculated MW of 72.1kDa according to NP_003168.2). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-KYLQQNRHVKDKN, from the internal region of the protein sequence according to NP_003168.2; NP_001128524.1. Corresponding Immunizing Peptide: Catalog #MBS425490
other info2 :
Important Note: This antibody is expected to recognise both reported isoforms (NP_003168.2; NP_001128524.1). Reported pairs of variants represent identical proteins (NP_003168.2 and NP_001167638.1; NP_001128524.1 and NP_001167639.1).
ncbi acc num :
NP_003168.2
ncbi gb acc num :
NM_003177.6
ncbi mol weight :
69,510 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Alpha-synuclein Signaling Pathway 137913!!Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway 576249!!Atypical NF-kappaB Pathway 137946!!B Cell Receptor Signaling Pathway 198909!!B Cell Receptor Signaling Pathway 83081!!B Cell Receptor Signaling Pathway 492!!BCR Signaling Pathway 138058!!Cytokine Signaling In Immune System Pathway 366171!!DAP12 Interactions Pathway 685549
ncbi summary :
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]