Goat anti-Myelin Protein zero Antibody | MyBioSource MBS421206 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Myelin Protein zero Antibody

catalog :

MBS421206

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421206

products type :

Antibody

products full name :

Goat anti-Myelin Protein zero Antibody

products short name :

Myelin Protein zero

products name syn :

myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); MPZ; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; P0; myelin protein zero antibody; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) antibody; MPZ antibody; CHM antibody; CMT1 antibody; CMT1B antibody; CMT2I antibody; CMT2J antibody; CMT4E antibody; CMTDI3 antibody; DSS antibody; HMSNIB antibody; MPP antibody; P0 antibody; Myelin Protein zero; Myelin Protein zero

other names :

myelin protein P0; Myelin protein P0; myelin protein P0; myelin protein zero; Myelin peripheral protein; MPP; Myelin protein zero

products gene name :

MPZ

other gene names :

MPZ; MPZ; P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; MPP

uniprot entry name :

MYP0_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

258

sequence :

DHSRSTKAVSEK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 28kDa band observed in Rat Spinal Cord lysates (calculated MW of 28.5kDa according to Human NP_000521.1 and of 27.7kDa according to Rat NP_058723.1). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-DHSRSTKAVSEK, from the internal region (near the C Terminus) of the protein sequence according to NP_000521.1. Epitope: Internal region (near the C Terminus)

other info2 :

Note: The presence of this PNS protein in Rat Spinal Cord is likely due to contamination with spinal roots during extraction from the animal.

ncbi gi num :

4505243

ncbi acc num :

NP_000521.1

ncbi gb acc num :

NM_000530.5

ncbi mol weight :

34,387 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Neural Crest Differentiation Pathway (672460)

ncbi summary :

This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]

uniprot summary :

myelin P0: a structural protein in peripheral nervous system Schwann cells. Forms an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. Defects cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, congenital hypomyelination neuropathy, and Roussy-Levy syndrome. Protein type: Membrane protein, integral; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 1q23.3. Cellular Component: basolateral plasma membrane; integral to plasma membrane; lysosome; myelin sheath; plasma membrane; rough endoplasmic reticulum. Molecular Function: structural molecule activity. Biological Process: negative regulation of apoptosis; synaptic transmission. Disease: Charcot-marie-tooth Disease, Axonal, Type 2i; Charcot-marie-tooth Disease, Axonal, Type 2j; Charcot-marie-tooth Disease, Demyelinating, Type 1b; Charcot-marie-tooth Disease, Dominant Intermediate D; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Roussy-levy Hereditary Areflexic Dystasia

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage