Goat anti-NCF1/p47phox Antibody | MyBioSource MBS421184 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NCF1/p47phox Antibody

catalog :

MBS421184

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421184

products type :

Antibody

products full name :

Goat anti-NCF1/p47phox Antibody

products short name :

NCF1/p47phox

products name syn :

Goat Anti-p47phox (mouse) Antibody; NCF1; p47phox; FLJ79451; NCF1A; NOXO2; SH3PXD1A; neutrophil cytosolic factor 1; Neutrophil cytosolic factor-1 (47kD); neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1); NADPH oxidase organizer 2; NCF1 antibody; p47phox antibody; FLJ79451 antibody; NCF1A antibody; NOXO2 antibody; SH3PXD1A antibody; neutrophil cytosolic factor 1 antibody; Neutrophil cytosolic factor-1 (47kD) antibody; neutrophil cytosolic factor 1 (47kD; chronic granulomatous disease; autosomal 1) antibody; NADPH oxidase organizer 2 antibody; NCF1 / p47phox

other names :

neutrophil cytosol factor 1; Neutrophil cytosol factor 1; neutrophil cytosol factor 1; neutrophil cytosolic factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox

products gene name :

NCF1

products gene name syn :

p47phox

other gene names :

NCF1; NCF1; NCF1A; NOXO2; p47phox; SH3PXD1A; NOXO2; SH3PXD1A; NCF-1

uniprot entry name :

NCF1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Pig; Expected from sequence similarity: Human, Mouse, Rat, Rabbit, Pig, Cow

sequence length :

390

sequence :

SESTKRKLASAV

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 20000. Western Blot: Approx 48kDa band observed in lysates of cell line U937 and of Mouse Thymus, and 50kDa observed in Pig Spleen lysates (calculated MW of 44.7kDa according to NP_000256.3). Recommended concentration: 0.5-1.5ug/ml.

other info1 :

Immunogen: Peptide with sequence C-SESTKRKLASAV, from the C Terminus of the protein sequence according to NP_000256.3. Epitope: C Terminus

ncbi gi num :

115298672

ncbi acc num :

NP_000256.3

ncbi gb acc num :

NM_000265.4

ncbi mol weight :

30,781 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Adaptive Immune System Pathway (1269171); Antigen Processing-Cross Presentation Pathway (1269195); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway (1269196); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Immune System Pathway (1269170)

ncbi summary :

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

uniprot summary :

p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. Protein type: EC 1.-.-.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: cytosol; extrinsic to membrane; NADPH oxidase complex. Molecular Function: electron carrier activity; phosphatidylinositol-3,4-bisphosphate binding; phosphoinositide binding; protein binding; SH3 domain binding; superoxide-generating NADPH oxidase activity. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular defense response; innate immune response; protein targeting to membrane; respiratory burst; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway. Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage