catalog number :
MBS421181
products full name :
Goat anti-Tryptophan hydroxylase 2 / TPH2 Antibody
products short name :
Tryptophan hydroxylase 2/TPH2
products name syn :
TPH2; tryptophan hydroxylase 2; HGNC:20692; FLJ37295; NTPH; neuronal tryptophan hydroxylase; ADHD7; MGC138871; MGC138872; tryptophan 5-monooxygenase 2; Goat Anti-TPH2 (aa16-29); TPH2; tryptophan hydroxylase 2; HGNC:20692; FLJ37295; NTPH; neuronal tryptophan hydroxylase; ADHD7; MGC138871; MGC138872; tryptophan 5-monooxygenase 2
other names :
tryptophan 5-hydroxylase 2; Tryptophan 5-hydroxylase 2; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2; neuronal tryptophan hydroxylase; tryptophan hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
products gene name :
TPH2
other gene names :
TPH2; TPH2; NTPH; ADHD7; NTPH
uniprot entry name :
TPH2_HUMAN
reactivity :
Human, Dog, Pig, Cow
sequence :
NKPNSGKNDDKGNK
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Brain Stem shows layered neuronal staining. Recommended concentration, 4-6ug/ml. Western Blot: Preliminary experiments in human brain lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-NKPNSGKNDDKGNK, from the internal region of the protein sequence according to NP_775489.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS428112
ncbi acc num :
NP_775489.2
ncbi gb acc num :
NM_173353.3
ncbi mol weight :
56,242 Da
ncbi pathways :
Amine-derived Hormones Pathway 160983!!Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway 413355!!Melatonin Biosynthesis, Tryptophan = Serotonin = Melatonin Pathway 468230!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!Monoamine Transport Pathway 198851!!SIDS Susceptibility Pathways 198901!!Serotonergic Synapse Pathway 525336!!Serotonin Transporter Activity Pathway 920962
ncbi summary :
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]