catalog number :
MBS421163
products full name :
Goat anti-AGR2 Antibody
products short name :
AGR2
products name syn :
AGR2; anterior gradient 2 homolog (Xenopus laevis); AG2; GOB-4; HAG-2; XAG-2; anterior gradient 2 homolog; anterior gradient 2 homolog (Xenepus laevis); secreted cement gland homolog; AGR2 antibody; anterior gradient 2 homolog (Xenopus laevis) antibody; AG2 antibody; GOB-4 antibody; HAG-2 antibody; XAG-2 antibody; anterior gradient 2 homolog antibody; anterior gradient 2 homolog (Xenepus laevis) antibody; secreted cement gland homolog antibody
other names :
anterior gradient protein 2 homolog; Anterior gradient protein 2 homolog; anterior gradient protein 2 homolog; anterior gradient 2, protein disulphide isomerase family member; HPC8; Secreted cement gland protein XAG-2 homolog
products gene name :
AGR2
other gene names :
AGR2; AGR2; AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116; AG2; AG-2; hAG-2
uniprot entry name :
AGR2_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 17-18kDa band observed in Human Colon, Duodenum and Lung lysates (calculated MW of 20. 0kDa according to NP_006399.1). Recommended concentration: up to 0. 01ug/ml.
other info1 :
Immunogen: Peptide with sequence C-GAKKDTKDSRPK, from the internal region of the protein sequence according to NP_006399.1. Epitope: Internal region
ncbi acc num :
NP_006399.1
ncbi gb acc num :
NM_006408.3
ncbi mol weight :
19,979 Da
uniprot summary :
AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. Protein type: Secreted, signal peptide; Secreted; Oncoprotein. Chromosomal Location of Human Ortholog: 7p21.3. Cellular Component: endoplasmic reticulum; extracellular space; mitochondrion. Molecular Function: epidermal growth factor receptor binding; protein binding; protein homodimerization activity. Biological Process: digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway