product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-SETMAR Antibody
catalog :
MBS421149
quantity :
0.1 mg
price :
300 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, cow
application :
western blot, enzyme immunoassay
more info or order :
product information
catalog number :
MBS421149
products type :
Antibody
products full name :
Goat anti-SETMAR Antibody
products short name :
SETMAR
products name syn :
SETMAR; SET domain and mariner transposase fusion gene; METNASE; SET domain and mariner transposase fusion; SETMAR antibody; SET domain and mariner transposase fusion gene antibody; METNASE antibody; SET domain and mariner transposase fusion antibody
other names :
histone-lysine N-methyltransferase SETMAR isoform 1; Histone-lysine N-methyltransferase SETMAR; histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion protein
products gene name :
SETMAR
other gene names :
SETMAR; SETMAR; Mar1; METNASE; Metnase
uniprot entry name :
SETMR_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Tested: Human; Expected from sequence similarity: Human, Cow
sequence length :
684
sequence :
RWQKCVDCNGSYFD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 70-75kDa band seen in Daudi lysate. Recommended for use at 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence RWQKCVDCNGSYFD, from the C Terminus of the protein sequence according to NP_006506.3. Epitope: C Terminus
ncbi gi num :
194306650
ncbi acc num :
NP_006506.3
ncbi gb acc num :
NM_006515.3
ncbi mol weight :
62,124 Da
ncbi pathways :
Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320)
ncbi summary :
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
uniprot summary :
SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43. Chromosomal Location of Human Ortholog: 3p26.1. Cellular Component: condensed chromosome; nucleus. Molecular Function: double-stranded DNA binding; endonuclease activity; histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H3-K4 specific); protein binding; protein homodimerization activity; single-stranded DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; structure-specific DNA binding; zinc ion binding. Biological Process: cell proliferation; DNA catabolic process, endonucleolytic; DNA double-strand break processing; DNA integration; double-strand break repair via nonhomologous end joining; histone H3-K36 methylation; histone H3-K4 methylation; replication fork processing
size1 :
0.1 mg
price1 :
300 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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