antibody

Goat anti-Caveolin 1 Antibody

MBS421139

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, immunocytochemistry, enzyme immunoassay

Antibody

Goat anti-Caveolin 1 Antibody

Caveolin 1

Goat Anti-Caveolin 1, Biotinylated Antibody; CAV1; caveolin 1, caveolae protein, 22kDa; HGNC: 1527; CAV; MSTP085; VIP21; caveolae protein, 22-kD; caveolin 1; caveolin 1 caveolae protein, 22kD; caveolin 1, alpha isoform; caveolin 1, beta isoform; cell growth-inhibiting protein 32; BSCL3; CGL3; MSTP08; CAV1 antibody; caveolin 1; caveolae protein; 22kDa antibody; HGNC: 1527 antibody; CAV antibody; MSTP085 antibody; VIP21 antibody; caveolae protein; 22-kD antibody; caveolin 1 antibody; caveolin 1 caveolae protein; 22kD antibody; caveolin 1; alpha isoform antibody; caveolin 1; beta isoform antibody; cell growth-inhibiting protein 32 antibody; BSCL3 antibody; CGL3 antibody; MSTP085 antibody; Caveolin 1; Caveolin 1

caveolin-1 isoform alpha; Caveolin-1; caveolin-1; caveolin 1

CAV1

CAV1; CAV1; CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085; CAV

CAV1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig

178

DELSEKQVYDAH

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 24+22kDa band observed in Human Spleen lysates. These bands correspond to earlier findings in literature with different antibodies (Wiechen et al Am J Pathol.2001 Mar;158(3): 833-9, PMID: 11238032). This protein has a calculated MW of 20.5kDa according to NP_001744.2. Recommended concentration: 0.01-0.03ug/ml. Immunocytochemsitry: An anonymous customer found positive results in ICC on Human HUVEC with a previous batch (from a different goat).

Immunogen: Peptide with sequence C-DELSEKQVYDAH, from the internal region of the protein sequence according to NP_001744.2. Epitope: Internal region

Note: No cross-reactivity expected to Caveolin 2 and Caveolin 3

15451856

NP_001744.2

NM_001753.4

17,023 Da

ALK1 Signaling Events Pathway (137968); Androgen Receptor Signaling Pathway (198806); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Basigin Interactions Pathway (1269376); Canonical Wnt Signaling Pathway (138032); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Direct P53 Effectors Pathway (137939); Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway (1269601); EGFR1 Signaling Pathway (198782)

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation. Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q31.1. Cellular Component: acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; cell cortex; cell surface; cilium; cytoplasmic vesicle; cytosol; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi membrane; integral to plasma membrane; intracellular; lipid particle; lipid raft; membrane; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein complex. Molecular Function: ATPase binding; cholesterol binding; enzyme binding; identical protein binding; nitric-oxide synthase binding; patched binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; structural molecule activity; syntaxin binding. Biological Process: angiogenesis; calcium ion homeostasis; calcium ion transport; cellular calcium ion homeostasis; cellular response to starvation; cholesterol efflux; cholesterol homeostasis; cholesterol transport; cytosolic calcium ion homeostasis; inactivation of MAPK activity; lactation; leukocyte migration; maintenance of cellular protein localization; mammary gland development; mammary gland involution; MAPKKK cascade; membrane depolarization; microtubule polymerization; negative regulation of BMP signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of MAPKKK cascade; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of pinocytosis; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; organ regeneration; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; protein homooligomerization; protein localization; receptor internalization; receptor mediated endocytosis of virus by host; regulation of blood coagulation; regulation of fatty acid metabolic process; regulation of nitric-oxide synthase activity; regulation of peptidase activity; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; response to bacterium; response to calcium ion; response to drug; response to estrogen stimulus; response to gamma radiation; response to glucocorticoid stimulus; response to hypoxia; response to nutrient; response to progesterone stimulus; sequestering of lipid; skeletal muscle development; T cell costimulation; triacylglycerol metabolic process; vasculogenesis; vasoconstriction; vesicle organization and biogenesis; wound healing. Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3

0.1 mg

300 USD