Goat anti-CSN2/TRIP15 Antibody | MyBioSource MBS421138 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-CSN2/TRIP15 Antibody

catalog :

MBS421138

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421138

products type :

Antibody

products full name :

Goat anti-CSN2/TRIP15 Antibody

products short name :

CSN2/TRIP15

products name syn :

COPS2; TRIP15; COPS2; CSN2; thyroid receptor interacting protein 15; SGN2; COP9 constitutive photomorphogenic homolog subunit 2; thyroid receptor interacting protein 15; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9, subunit 2; COPS2 antibody; TRIP15 antibody; COPS2 antibody; CSN2 antibody; thyroid receptor interacting protein 15 antibody; SGN2 antibody; COP9 constitutive photomorphogenic homolog subunit 2 antibody; thyroid receptor interacting protein 15 antibody; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody; COP9; subunit 2 antibody; ALIEN antibody; COP9 signalosome complex subunit 2 antibody; JAB1-containing signalosome subunit 2 antibody; CSN2 / TRIP15

other names :

COP9 signalosome complex subunit 2 isoform 1; COP9 signalosome complex subunit 2; COP9 signalosome complex subunit 2; COP9 signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15

products gene name :

COPS2

products gene name syn :

CSN2; TRIP15

other gene names :

COPS2; COPS2; CSN2; SGN2; ALIEN; TRIP15; CSN2; TRIP15; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15

uniprot entry name :

CSN2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

443

sequence :

LNSLNQAVVSKLA

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Thyroid Gland shows nclear and cytoplasm staining in activated epithelial cells Recommended concentration, 3-5ug/ml. Western Blot: approx. 48kDa band observed in Human Brain, Mouse Brain lysates and in lysates of Mouse putuitary cell line NIH3T3 (calculated MW of 51.6kDa according to NP_004227.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-LNSLNQAVVSKLA, from the C Terminus of the protein sequence according to NP_004227.1; NP_001137359.1. Epitope: C Terminus

products references :

Besse A, Campos AD, Webster WK, Darnay BG.; TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.; Biochem Biophys Res Commun.2007 Aug 3;359(3): 660-4.; Pubmed 17544371

ncbi gi num :

4759264

ncbi acc num :

NP_004227.1

ncbi gb acc num :

NM_004236.3

ncbi mol weight :

52,405 Da

ncbi pathways :

DNA Damage Recognition In GG-NER Pathway (1309113); DNA Repair Pathway (1270350); Formation Of TC-NER Pre-Incision Complex Pathway (1309118); Global Genome Nucleotide Excision Repair (GG-NER) Pathway (1309112); Nucleotide Excision Repair Pathway (1309111); Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway (1309117)

uniprot summary :

COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 15q21.2. Cellular Component: cytoplasm; nucleoplasm; signalosome. Molecular Function: protein binding; signal transducer activity; transcription corepressor activity. Biological Process: cell proliferation; cullin deneddylation; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleotide-excision repair, DNA damage recognition; signal transduction; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage