Goat anti-ADAM17 / TACE Antibody | MyBioSource MBS421126 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ADAM17 / TACE Antibody

catalog :

MBS421126

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421126

products type :

Antibody

products full name :

Goat anti-ADAM17 / TACE Antibody

products short name :

ADAM17/TACE

products name syn :

ADAM17; TACE; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor; alpha; converting enzyme); CSVP; cSVP; CD156b; CD156b; MGC71942; TACE; cSVPADAM metallopeptidase domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor; alpha; converting enzyme); snake venom-like protease; ADAM metallopeptidase domain 17; ADAM18; CD156B; ADAM metallopeptidase domain 18; snake venom-like protease; tumor necrosis factor; alpha; converting enzyme; TACE; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); CSVP; cSVP; CD156b; CD156b; MGC71942; TACE; cSVPADAM metallopeptidase domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); snake venom-like protease; ADAM metallopeptidase domain 17; ADAM18; CD156B; ADAM metallopeptidase domain 18; snake venom-like protease; tumor necrosis factor, alpha, converting enzyme

other names :

disintegrin and metalloproteinase domain-containing protein 17 preproprotein; Disintegrin and metalloproteinase domain-containing protein 17; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; ADAM metallopeptidase domain 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b

products gene name :

ADAM17

other gene names :

ADAM17; ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1; CSVP; TACE; ADAM 17

uniprot entry name :

ADA17_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Mouse, Rat

sequence length :

824

sequence :

LQRQNRVDSKETEC

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: Approx 100kDa band observed in Human Testis lysates and approx 125kDa in lysates of cell lines Daudi, HeLa and Jurkat (calculated MW of 93.0kDa according to NP_003174.3). The observed molecular weights correspond to earlier findings in literature with different antibodies (Le Gall et al, J Cell Sci. 2010 Nov 15;123(Pt22):3913-22; PMID: 20980382). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.

other info1 :

Epitope: C Terminus. Immunogen: Peptide with sequence LQRQNRVDSKETEC, from the C Terminus of the protein sequence according to NP_003174.3. Corresponding Immunizing Peptide: Catalog #MBS426989

other info2 :

Important Note: This antibody is expected to recognise isoform 1 (represented by NP_003174) and not isoform 2 (represented by NP_068604).

ncbi gi num :

73747889

ncbi acc num :

NP_003174.3

ncbi gb acc num :

NM_003183.4

ncbi mol weight :

78,543 Da

ncbi pathways :

Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Apoptosis Pathway 105648!!BDNF Signaling Pathway 712093!!Collagen Degradation Pathway 730309!!Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway 771591!!Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway 771595!!Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway 771593

ncbi summary :

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage