catalog number :
MBS421120
products full name :
Goat anti-Arginase, type 1 / ARG1 Antibody
products short name :
Arginase, type 1/ARG1
products name syn :
ARG1; arginase; type I; arginase; liver; A-I; Goat Anti-Arginase I; arginase, type I; arginase, liver; A-I;
other names :
arginase-1 isoform 2; Arginase-1; arginase-1; arginase, liver; type I arginase; liver-type arginase; arginase 1; Liver-type arginase; Type I arginase
products gene name :
ARG1
other gene names :
ARG1; ARG1
uniprot entry name :
ARGI1_HUMAN
reactivity :
Human, Dog, Mouse
sequence :
REGNHKPIDYLNPPK
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 37kDa band observed in Human Liver lysates (calculated MW of 34.7kDa according to NP_000036.2. Recommended concentration: 0.01-0.03ug/ml. An anonymous customer found positive results in WB on Mouse leukaemic monocyte macrophage cells (RAW 264.7). Peptide ELISA: antibody detection limit dilution 1:2000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-REGNHKPIDYLNPPK, from the C Terminus of the protein sequence according to NP_000036.2. Corresponding Immunizing Peptide: Catalog #MBS426571
other info2 :
Important Note: Please note that ARG1 is not expressed in Human M2 macrophages, but it is in other species (eg rodents).
ncbi acc num :
NP_000036.2
ncbi gb acc num :
NM_000045.3
ncbi mol weight :
25,356 Da
ncbi pathways :
ATF-2 Transcription Factor Network Pathway 138006!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!IL4-mediated Signaling Events Pathway 137933!!Metabolic Pathways 132956!!Metabolism Pathway 477135
ncbi summary :
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]