Goat anti-Nur77/TR3 (isoform a) Antibody | MyBioSource MBS421106 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Nur77/TR3 (isoform a) Antibody

catalog :

MBS421106

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421106

products type :

Antibody

products full name :

Goat anti-Nur77/TR3 (isoform a) Antibody

products short name :

Nur77/TR3

products name syn :

NR4A1; NUR77; nuclear receptor subfamily 4, group A, member 1; GFRP1; HMR; MGC9485; N10; NAK-1; NGFIB; NP10; TR3; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; orphan nuclear receptor HM; NR4A1 antibody; NUR77 antibody; nuclear receptor subfamily 4; group A; member 1 antibody; GFRP1 antibody; HMR antibody; MGC9485 antibody; N10 antibody; NAK-1 antibody; NGFIB antibody; NP10 antibody; TR3 antibody; TR3 orphan receptor antibody; early response protein NAK1 antibody; growth factor-inducible nuclear protein N10 antibody; hormone receptor antibody; orphan nuclear receptor HMR antibody; steroid receptor TR3 antibody; Nur77 / TR3 (isoform a)

other names :

nuclear receptor subfamily 4 group A member 1 isoform 1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3

products gene name :

NR4A1

products gene name syn :

Nur77; TR3

other gene names :

NR4A1; NR4A1; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77; GFRP1; HMR; NAK1; Nur77

uniprot entry name :

NR4A1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

598

sequence :

GRLPSKPKQPPDAS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60kDa band observed in Human Thyroid gland lysates (calculated MW of 64.5kDa according to NP_002126.2 and NP_775180.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-GRLPSKPKQPPDAS, from the internal region of the protein sequence according to NP_002126.2; NP_775180.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise isoform a (NP_002126.2 and NP_775180.1) only.

ncbi gi num :

21361342

ncbi acc num :

NP_002126.2

ncbi gb acc num :

NM_002135.4

ncbi mol weight :

33,754 Da

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (1269190); Adaptive Immune System Pathway (1269171); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Constitutive Signaling By AKT1 E17K In Cancer Pathway (1268881); Corticotropin-releasing Hormone Pathway (920957); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Protein type: DNA-binding; Apoptosis; Nuclear receptor. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: cytoplasm; nuclear membrane; nucleoplasm; nucleus. Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding. Biological Process: cell migration during sprouting angiogenesis; fat cell differentiation; intracellular receptor-mediated signaling pathway; negative regulation of cell cycle; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage