product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-DKK4 Antibody
catalog :
MBS421072
quantity :
0.1 mg
price :
300 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog
application :
western blot, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS421072
products type :
Antibody
products full name :
Goat anti-DKK4 Antibody
products short name :
DKK4
products name syn :
DKK4; dickkopf homolog 4 (Xenopus laevis); DKK-4; hdkk-4; Dickkopf gene 4; dickkopf (Xenopus laevis) homolog 4; MGC129562; MGC129563; dickkopf homolog 4; DKK4 antibody; dickkopf homolog 4 (Xenopus laevis) antibody; DKK-4 antibody; hdkk-4 antibody; Dickkopf gene 4 antibody; dickkopf (Xenopus laevis) homolog 4 antibody; MGC129562 antibody; MGC129563 antibody; dickkopf homolog 4 antibody
other names :
dickkopf-related protein 4; Dickkopf-related protein 4; dickkopf-related protein 4; dickkopf WNT signaling pathway inhibitor 4
products gene name :
DKK4
other gene names :
DKK4; DKK4; DKK-4; Dickkopf-4; Dkk-4; hDkk-4
uniprot entry name :
DKK4_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
sequence length :
224
sequence :
RQHARLRVCQKIEKL
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 30-35kDa band seen in Jurkat lysate. Recommended for use at 1-3ug/ml. Please note that literature indicates DKK4 is detected as three major immunoreactive species of approx. 40 kDa [form (i)], 30-32 kDa [form (ii)] and 15-17 kDa [form (iii)]. We believe this antibody will recognise 30-32kDa species of DKK4.
other info1 :
Immunogen: Peptide with sequence RQHARLRVCQKIEKL, from the C Terminus of the protein sequence according to NP_055235.1. Epitope: C Terminus
ncbi gi num :
7657025
ncbi acc num :
NP_055235.1
ncbi gb acc num :
NM_014420.2
ncbi mol weight :
24,876 Da
ncbi pathways :
Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855); Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway (1268923); Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway (1269608); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (1269379); Signaling By WNT In Cancer Pathway (1268906); Signaling By Wnt Pathway (1269594); TCF Dependent Signaling In Response To WNT Pathway (1269599); Wnt Signaling Pathway (83061)
ncbi summary :
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
uniprot summary :
DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. Protein type: Inhibitor; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8p11.2-p11.1. Cellular Component: extracellular region. Biological Process: multicellular organismal development; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
size1 :
0.1 mg
price1 :
300 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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