Goat anti-NOTCH2 Antibody | MyBioSource MBS421069 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NOTCH2 Antibody

catalog :

MBS421069

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421069

products type :

Antibody

products full name :

Goat anti-NOTCH2 Antibody

products short name :

NOTCH2

products name syn :

NOTCH2; Notch homolog 2 (Drosophila); HGNC: 7882; hN2; Notch (Drosophila) homolog 2; OTTHUMP00000059536; notch 2; AGS2; NOTCH2 antibody; Notch homolog 2 (Drosophila) antibody; HGNC: 7882 antibody; hN2 antibody; Notch (Drosophila) homolog 2 antibody; OTTHUMP00000059536 antibody; notch 2 antibody; AGS2 antibody

other names :

neurogenic locus notch homolog protein 2 isoform 1 preproprotein; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; notch 2

products gene name :

NOTCH2

other gene names :

NOTCH2; NOTCH2; hN2; AGS2; HJCYS; N2ICD

uniprot entry name :

NOTC2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

2471

sequence :

ERTPSHSGHLQGEH

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments in lysates of human brain, heart, kidney, liver, lung and skeletal muscle gave no specific signal but low background (at antibody concentration up to 1ug/ml).

other info1 :

Immunogen: Peptide with sequence C-ERTPSHSGHLQGEH, from the internal region of the protein sequence according to NP_077719.2. Epitope: Internal region

ncbi gi num :

24041035

ncbi acc num :

NP_077719.2

ncbi gb acc num :

NM_024408.3

ncbi mol weight :

265,405 Da

ncbi pathways :

Defective LFNG Causes SCDO3 Pathway (1383053); Delta-Notch Signaling Pathway (198879); Disease Pathway (1268854); Diseases Associated With O-glycosylation Of Proteins Pathway (1383049); Diseases Of Glycosylation Pathway (1269010); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); MicroRNAs In Cancer Pathway (852705)

ncbi summary :

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p13-p11. Cellular Component: cell surface; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex. Molecular Function: calcium ion binding; protein binding; receptor activity. Biological Process: apoptosis; bone remodeling; cell cycle arrest; cell fate determination; cell growth; hemopoiesis; intracellular receptor-mediated signaling pathway; marginal zone B cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell proliferation; nervous system development; Notch signaling pathway; organ morphogenesis; positive regulation of Ras protein signal transduction; regulation of developmental process; regulation of transcription, DNA-dependent; stem cell maintenance; tissue regeneration; transcription initiation from RNA polymerase II promoter. Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage