catalog number :
MBS421068
products full name :
Goat anti-58K Golgi protein(N-Term)/FTCD Antibody
products short name :
58K Golgi protein(N-Term)/FTCD
products name syn :
FTCD; LCHC1; formiminotransferase cyclodeaminase; formimidoyltransferase cyclodeaminase; Goat Anti-58KGolgi protein(Internal)/FTCD; FTCD; LCHC1; formiminotransferase cyclodeaminase; formimidoyltransferase cyclodeaminase
other names :
formimidoyltransferase-cyclodeaminase; Formimidoyltransferase-cyclodeaminase; formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase; formimidoyltransferase cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
products gene name :
FTCD
other gene names :
FTCD; FTCD; LCHC1; FTCD
uniprot entry name :
FTCD_HUMAN
reactivity :
Human, Mouse, Pig
sequence :
SQLVECVPNFSEGKNQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Liver shows distinct staining of membranes and cytoplasm in a selection of hepatocytes. Recommended concentration, 3-5ug/ml. Western Blot: A 55-60kDa band observed in Human Liver lysate (calculated MW of 58.9kDa according to NP_006648. Recommended concentration: 0.03-0.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence SQLVECVPNFSEGKNQ, from the N Terminus of the protein sequence according to NP_006648.1; NP_996848.1. Corresponding Immunizing Peptide: Catalog #MBS428511
other info2 :
Important Note: Variants (NP_006648.1; NP_996848.1) encode the same protein.
products references :
Hagiwara H, Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Takata K.; Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome.; Histochem Cell Biol. 2006 Aug; 126(2):251-9.; Pubmed 16534631
ncbi acc num :
NP_006648.1
ncbi gb acc num :
NM_006657.2
ncbi mol weight :
16,503 Da
ncbi pathways :
Histidine Catabolism Pathway 106186!!Histidine Metabolism Pathway 82958!!Histidine Metabolism Pathway 324!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!One Carbon Metabolism Pathway 198756!!One Carbon Pool By Folate Pathway 83008!!One Carbon Pool By Folate Pathway 393!!Histidine Degradation III Pathway 142356
ncbi summary :
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]