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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-INDO / IDO Antibody
catalog :
MBS421061
quantity :
0.1 mg
price :
290 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS421061
products type :
Antibody
products full name :
Goat anti-INDO / IDO Antibody
products short name :
INDO/IDO
products name syn :
INDO; indoleamine-pyrrole 2; 3 dioxygenase; HGNC:6059; CD107B; IDO; Indoleamine 2; 3-dioxygenase; indole 2; 3-dioxygenase; IDO1; IDO1; INDO; indoleamine-pyrrole 2,3 dioxygenase; HGNC:6059; CD107B; IDO; Indoleamine 2,3-dioxygenase; indole 2,3-dioxygenase
other names :
indoleamine 2,3-dioxygenase 1; Indoleamine 2,3-dioxygenase 1; indoleamine 2,3-dioxygenase 1; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; indoleamine 2,3-dioxygenase 1; Indoleamine-pyrrole 2,3-dioxygenase
products gene name :
IDO1
other gene names :
IDO1; IDO1; IDO; INDO; IDO-1; IDO; INDO; IDO-1
uniprot entry name :
I23O1_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Human, Mouse, Rat, Dog
sequence length :
403
sequence :
CVLANWKKKDPNK
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Colon shows textured staining in the cytoplasm of absorptive cells. Recommended concentration, 4-6ug/ml. Western Blot: Preliminary experiments gave bands at approx 28kDa and 25kDa in lysates of Human Spleen and Tonsil and in Mouse Brain lysate after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 45.3kDa according to NP_002155.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands). Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence CVLANWKKKDPNK, from the internal region of the protein sequence according to NP_002155.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425254
ncbi gi num :
4504577
ncbi acc num :
NP_002155.1
ncbi gb acc num :
NM_002164.5
ncbi mol weight :
45,326 Da
ncbi pathways :
African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!NAD Biosynthesis II (from Tryptophan) Pathway 138368!!Tryptophan Catabolism Pathway 106190!!Tryptophan Metabolism Pathway 82964!!Tryptophan Metabolism Pathway 198850!!Tryptophan Metabolism Pathway 332
ncbi summary :
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
size :
0.1 mg
price :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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