Goat anti-CIAS1 / cryopyrin (C Terminus) Antibody | MyBioSource MBS421057 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-CIAS1 / cryopyrin (C Terminus) Antibody

catalog :

MBS421057

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat, cow

application :

western blot, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421057

products type :

Antibody

products full name :

Goat anti-CIAS1 / cryopyrin (C Terminus) Antibody

products short name :

CIAS1/cryopyrin

products name syn :

NLRP3; CIAS1; FCU; MWS; FCAS; NALP3; C1orf7; PYPAF1; AII/AVP; AGTAVPRL; CRYOPYRIN; cold autoinflammatory syndrome 1; cryopyrin; Muckle-Wells syndrome; chromosome 1 open reading frame 7; PYRIN-containing APAF1-like protein 1; neuronal apoptosis inhibitor protein 3; angiotensin/vasopressin receptor AII/AVP-like; NLR family; pyrin domain containing 3; AII; AVP; CLR1.1; FLJ95925; AII/AVP receptor-like; NACHT domain-; leucine-rich repeat-; and PYD-containing protein 3; NACHT; LRR and PYD containing protein 3; PYRIN-containing APAF1-like protein 1; nucleotide-binding oligomerization domain; leucine rich repeat and pyrin domain containing 3; Goat Anti-Cryopirin / NALP3 / NLRP3; NLRP3; CIAS1; FCU; MWS; FCAS; NALP3; C1orf7; PYPAF1; AII/AVP; AGTAVPRL; CRYOPYRIN; cold autoinflammatory syndrome 1; cryopyrin; Muckle-Wells syndrome; chromosome 1 open reading frame 7; PYRIN-containing APAF1-like protein 1; neuronal apoptosis inhibitor protein 3; angiotensin/vasopressin receptor AII/AVP-like; NLR family, pyrin domain containing 3; AII; AVP; CLR1.1; FLJ95925; AII/AVP receptor-like; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; PYRIN-containing APAF1-like protein 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3

other names :

NACHT, LRR and PYD domains-containing protein 3 isoform a; NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; cryopyrin; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; NLR family, pyrin domain containing 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1

products gene name :

NLRP3

other gene names :

NLRP3; NLRP3; AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL; C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1

uniprot entry name :

NALP3_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Rat, Cow

sequence length :

1036

sequence :

EKPELTVVFEPSW

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Flow Cytometry (FC/FACS), Western Blot (WB)

app notes :

Western Blot: No signal obtained yet but low background observed in A431 lysates at up to 1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000. Flow cytometry: Customer finds it to work well in FC on human monocytes.

other info1 :

Epitope: C Terminus. Immunogen: Peptide with sequence C-EKPELTVVFEPSW, from the C Terminus of the protein sequence according to NP_001073289.1; NP_004886.3; NP_899632.1; NP_001120933.1; NP_001120934.1. Corresponding Immunizing Peptide: Catalog #MBS428504

other info2 :

Important Note: Variants (NP_001073289.1; NP_004886.3) encode the same isoform.

ncbi gi num :

119395764

ncbi acc num :

NP_001073289.1

ncbi gb acc num :

NM_001079821.2

ncbi mol weight :

115,968 Da

ncbi pathways :

Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!NOD Pathway 198792!!NOD-like Receptor Signaling Pathway 122191!!NOD-like Receptor Signaling Pathway 122131!!Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways 366164!!Pertussis Pathway 218111

ncbi summary :

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage