Goat anti-ABCC4/MRP4 Antibody | MyBioSource MBS421051 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ABCC4/MRP4 Antibody

catalog :

MBS421051

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421051

products type :

Antibody

products full name :

Goat anti-ABCC4/MRP4 Antibody

products short name :

ABCC4/MRP4

products name syn :

Goat Anti-ABCC4 (aa70-82) Antibody; ABCC4; MRP4; MOATB; MOAT-B; EST170205; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; canalicular multispecific organic anion transporter (ABC superfamily); Multidrug Resistance Protein 4; RP11-74A12.1; ATP-binding cassette, sub-family C, member; ABCC4 antibody; MRP4 antibody; MOATB antibody; MOAT-B antibody; EST170205 antibody; ATP-binding cassette; sub-family C (CFTR/MRP); member 4 antibody; canalicular multispecific organic anion transporter (ABC superfamily) antibody; Multidrug Resistance Protein 4 antibody; RP11-74A12.1 antibody; ATP-binding cassette; sub-family C; member 4 antibody; bA464I2.1 (ATP-binding cassette; sub-family C (CFTR/MRP); member 4) antibody; canalicular multispecific organic anion transporter (ABC superfamily) antibody; multidrug resistance-associated protein 4; multispecific organic anion transporter B antibody; ABCC4 / MRP4

other names :

multidrug resistance-associated protein 4 isoform 1; Multidrug resistance-associated protein 4; multidrug resistance-associated protein 4; ATP binding cassette subfamily C member 4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B

products gene name :

ABCC4

other gene names :

ABCC4; ABCC4; MRP4; MOATB; MOAT-B; MRP4; MOAT-B

uniprot entry name :

MRP4_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat

sequence length :

1325

sequence :

CNGQPSTLTIFETAL

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Prostate shows strong cytoplasmic staining in small flat basal cells and weak cytoplasmic staining in the columnar secretory cells of the epithelium. Recommended concentration, 2-4ug/ml. Western Blot: Approx 170kDa band observed in rat renal cortex membranes (calculated MW of 149kDa according to Rat NP_596902.1 and 150kDa according to Human NP_005836.2). Data obtained from a previous batch and kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald, Germany. Recommended concentration: 1-3ug/ml. Immunocytochemsitry/Immunofluorescence: This antibody (from a previous batch) has been successfully used in ICC/IF for human primary hepatocytes as described in the following paper: Xu et al, Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G126-35, PMID: 20395535.

other info1 :

Immunogen: Peptide with sequence CNGQPSTLTIFETAL, from the C Terminus of the protein sequence according to NP_005836.2. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognize isoform 1 (NP_005836.2) only.

ncbi gi num :

157502201

ncbi acc num :

NP_005836.2

ncbi gb acc num :

NM_005845.4

ncbi mol weight :

88,138 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (1269904); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Drug Induction Of Bile Acid Pathway (698755); Fluoropyrimidine Activity Pathway (198778); Hemostasis Pathway (1269340); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

uniprot summary :

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. Protein type: Transporter; Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 13q32. Cellular Component: basolateral plasma membrane; integral to membrane; membrane; plasma membrane; platelet dense granule membrane. Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism. Biological Process: cilium biogenesis; platelet degranulation; prostaglandin secretion; transmembrane transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage