catalog number :
MBS421037
products full name :
Goat anti-NFATC4 Antibody
products short name :
NFATC4
products name syn :
NFATC4; NFAT3; NF-ATc4; nuclear factor of activated T-cells; cytoplasmic; calcineurin-dependent 4; T cell transcription factor NFAT3; nuclear factor of activated T-cells; cytoplasmic 4; Goat Anti-NFATC4 / NFAT3; NFATC4; NFAT3; NF-ATc4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T cell transcription factor NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
other names :
nuclear factor of activated T-cells, cytoplasmic 4 isoform 2; Nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic 4; T-cell transcription factor NFAT3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T-cell transcription factor NFAT3; NF-AT3
products gene name :
NFATC4
other gene names :
NFATC4; NFATC4; NFAT3; NF-AT3; NF-ATC4; NFAT3; NF-ATc4; NFATc4; NF-AT3
uniprot entry name :
NFAC4_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Placenta shows weak nuclear staining in trophoblasts. Recommended concentration, 2.5-3.8ug/ml. Western Blot: No signal obtained yet but low background observed in MOLT-4, Jurkat, A431, HeLa, Human Brain and Human Heart lysates at upto 2ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-SGFPAPPGEEPPA, from the C Terminus of the protein sequence according to NP_004545.2; NP_001185894.1; NP_001185895.1; NP_001185896.1. Corresponding Immunizing Peptide: Catalog #MBS428202
other info2 :
Important Note: This antibody is expected to recognise isoform 2, 3, 4 and 5 (NP_004545.2; NP_001185894.1; NP_001185895.1; NP_001185896.1 respectively).
ncbi acc num :
NP_004545.2
ncbi gb acc num :
NM_004554.4
ncbi mol weight :
8,950 Da
ncbi pathways :
Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!BDNF Signaling Pathway 712093!!ErbB2/ErbB3 Signaling Events Pathway 137955!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Heart Development Pathway 198802!!Hepatitis B Pathway 694606!!MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!Oxytocin Signaling Pathway 952859
ncbi summary :
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]