catalog number :
MBS421032
products full name :
Goat anti-MTR Antibody
products short name :
MTR
products name syn :
MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate-homocysteine methyltransferase 1; FLJ33168; FLJ43216; FLJ45386; MS; cblG; cobalamin-dependent methionine synthase; methionine synthase; vitamin-B12 dependent methionine synthase; MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate-homocysteine methyltransferase 1; FLJ33168, FLJ43216; FLJ45386; MS; cblG; cobalamin-dependent methionine synthase; methionine synthase; vitamin-B12 dependent methionine synthase
other names :
methionine synthase isoform 1; Methionine synthase; methionine synthase; cobalamin-dependent methionine synthase; vitamin-B12 dependent methionine synthase; 5-methyltetrahydrofolate-homocysteine methyltransferase 1; 5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS
other gene names :
MTR; MTR; MS; HMAG; cblG; MS
uniprot entry name :
METH_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig
sequence :
VEKWLGPILGYDTD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Adrenal Gland shows cytoplasm staining in the cortex. Recommended concentration, 3-5ug/ml. Western Blot: Approx 150kDa band seen in HeLa and Jurkat cell lysates. Recommended for use at 1-3 ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-VEKWLGPILGYDTD, from the C Terminus of the protein sequence according to NP_000245.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426478
ncbi acc num :
NP_000245.2
ncbi gb acc num :
NM_000254.2
ncbi mol weight :
140,527 Da
ncbi pathways :
Biological Oxidations Pathway 105698!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway 833804!!Cysteine And Methionine Metabolism Pathway 104488!!Cysteine And Methionine Metabolism Pathway 103421!!Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001
ncbi summary :
This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]