antibody

Goat anti-KPNA2 / IPOA1 Antibody

MBS421014

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, immunocytochemistry, enzyme immunoassay

Antibody

Goat anti-KPNA2 / IPOA1 Antibody

KPNA2/IPOA1

KPNA2; IPOA1 QIP2; RCH1; SRP1alpha; karyopherin alpha 2 (RAG cohort 1; importin alpha 1); RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; karyopherin alpha 2; pendulin; KPNA2; IPOA1 QIP2; RCH1; SRP1alpha; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; karyopherin alpha 2; pendulin

importin subunit alpha-1; Importin subunit alpha-1; importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha

KPNA2

KPNA2; KPNA2; QIP2; RCH1; IPOA1; SRP1alpha; RCH1; SRP1

IMA1_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog

529

QVQDGAPGTFNF

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Western Blot: Approx 55-60kDa band observed in Hela lysates (predicted size of approx. 58kDa according to NP_002257.1). Recommended for use at 0.1-0.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000. Immunofluorescence: In 4% formaldahyde-fixed HeLa staining is mostly cytoplasmic, with some nuclear staining and clear nuclear pore staining.

Epitope: C Terminus. Immunogen: Peptide with sequence C-QVQDGAPGTFNF, from the C Terminus of the protein sequence according to NP_002257.1.

Corresponding Immunizing Peptide: Catalog #MBS425004

4504897

NP_002257.1

NM_002266.2

57,862 Da

Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Cytokine Signaling In Immune System Pathway 366171!!ISG15 Antiviral Mechanism Pathway 530761!!Immune System Pathway 106386!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Interferon Signaling Pathway 187103!!Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway 138015!!Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway 137953!!Signaling Events Mediated By TCPTP Pathway 169350

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]

0.1 mg

290 USD