catalog number :
MBS421007
products full name :
Goat anti-LASP1 (N Terminus) Antibody
products short name :
LASP1
products name syn :
Goat Anti-LASP1 (internal region) Antibody; LASP1; LIM and SH3 protein 1; MLN50; Lasp-1; LIM and SH3 protein; LASP1 antibody; LIM and SH3 protein 1 antibody; MLN50 antibody; Lasp-1 antibody; LIM and SH3 protein antibody; LASP1 (N Terminus)
other names :
LIM and SH3 domain protein 1 isoform a; LIM and SH3 domain protein 1; LIM and SH3 domain protein 1; LIM and SH3 protein 1; Metastatic lymph node gene 50 protein; MLN 50
products gene name :
LASP1
other gene names :
LASP1; LASP1; MLN50; Lasp-1; MLN50; LASP-1; MLN 50
uniprot entry name :
LASP1_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 35kDa band observed in Human Brain (Cerebellum) and Human Colon, Duodenum, Liver and Pancreas lysates (calculated MW of 29.7kDa according to NP_006139.1). Recommended concentration: 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence NPNCARCGKIVYP, from the N Terminus of the protein sequence according to NP_006139.1. Epitope: N Terminus
ncbi acc num :
NP_006139.1
ncbi gb acc num :
NM_006148.3
ncbi mol weight :
23,181 Da
ncbi summary :
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
uniprot summary :
Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization. Protein type: Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: 17q11-q21.3. Cellular Component: cortical actin cytoskeleton; focal adhesion. Molecular Function: actin filament binding; ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity; zinc ion binding. Biological Process: ion transport; positive regulation of signal transduction