catalog number :
MBS421006
products full name :
Goat anti-ADH7 Antibody
products short name :
ADH7
products name syn :
ADH7; alcohol dehydrogenase 7 (class IV); mu or sigma polypeptide; ADH-4; alcohol dehydrogenase-7; class IV alcohol dehydrogenase 7 mu or sigma subunit; gastric alcohol dehydrogenase.; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; ADH-4; alcohol dehydrogenase-7; class IV alcohol dehydrogenase 7 mu or sigma subunit; gastric alcohol dehydrogenase.
other names :
alcohol dehydrogenase class 4 mu/sigma chain isoform 2; Alcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase class 4 mu/sigma chain; retinol dehydrogenase; alcohol dehydrogenase-7; alcohol dehydrogenase VII; gastric alcohol dehydrogenase; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase; alcohol dehydrogenase class IV mu/sigma chain; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
products gene name :
ADH7
other gene names :
ADH7; ADH7; ADH4
uniprot entry name :
ADH7_HUMAN
reactivity :
Human, Mouse
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 26kDa band in lysates of Human Duodenum and Liver and of Rat stomach after 0.2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 41.5kDa according to NP_000664.2. The 26kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence CISPKDSTKPISE, from the internal region of the protein sequence according to NP_000664.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425788
ncbi acc num :
NP_000664.2
ncbi gb acc num :
NM_000673.4
ncbi mol weight :
42,467 Da
ncbi pathways :
Biological Oxidations Pathway 105698!!Chemical Carcinogenesis Pathway 673221!!Chemical Carcinogenesis Pathway 673237!!Drug Metabolism - Cytochrome P450 Pathway 83032!!Drug Metabolism - Cytochrome P450 Pathway 427!!Ethanol Oxidation Pathway 105715!!Fatty Acid Omega Oxidation Pathway 198915!!Fatty Acid Degradation Pathway 82935!!Fatty Acid Degradation Pathway 296!!Glycolysis / Gluconeogenesis Pathway 82926
ncbi summary :
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]