catalog number :
MBS421003
products full name :
Goat anti-GPR119 Antibody
products short name :
GPR119
products name syn :
GPR119; G protein-coupled receptor 119; RP1-20I3.4; GPCR2N: MGC119957N: hGPCR2; G-protein coupled receptor 2; GPR119 antibody; G protein-coupled receptor 119 antibody; RP1-20I3.4 antibody; GPCR2N: MGC119957N: hGPCR2 antibody; G-protein coupled receptor 2 antibody
other names :
glucose-dependent insulinotropic receptor; Glucose-dependent insulinotropic receptor; glucose-dependent insulinotropic receptor; G protein-coupled receptor 119; G-protein coupled receptor 119
products gene name :
GPR119
other gene names :
GPR119; GPR119; GPCR2
uniprot entry name :
GP119_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Pig
sequence :
SARNCGPERPRESS
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx.38kDa band observed in Human Ovary lysates (calculated MW of 36.9kDa according to NP_848566.1). Recommended concentration: 0.3-1ug/ml.
other info1 :
Immunogen: Peptide with sequence SARNCGPERPRESS, from the C Terminus (near) of the protein sequence according to NP_848566.1. Epitope: C Terminus (near)
ncbi acc num :
NP_848566.1
ncbi gb acc num :
NM_178471.2
ncbi mol weight :
36,889 Da
ncbi pathways :
Incretin Synthesis, Secretion, And Inactivation Pathway (1268750); Insulin Secretion Pathway (777534); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway (1268751); Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway (1268752); CAMP Signaling Pathway (1017634); CAMP Signaling Pathway (1019520)
ncbi summary :
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
uniprot summary :
GPR119: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: Xq26.1. Cellular Component: integral to membrane; plasma membrane; receptor complex. Molecular Function: G-protein coupled receptor activity; phosphatidylcholine binding. Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion