antibody

Goat anti-Sak/STK18/PLK4 Antibody

MBS420966

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-Sak/STK18/PLK4 Antibody

Sak/STK18/PLK4

PLK4; Sak; polo-like kinase 4 (Drosophila); serine/threonine kinase 18; SAK; Snk Akin Kinase; polo-like kinase 4; protein-serine/threonine kinase; STK18; serine/threonine protein kinase SAK; PLK4 antibody; Sak antibody; polo-like kinase 4 (Drosophila) antibody; serine/threonine kinase 18 antibody; SAK antibody; Snk Akin Kinase antibody; polo-like kinase 4 antibody; protein-serine/threonine kinase antibody; STK18 antibody; serine/threonine protein kinase SAK antibody; Sak / STK18 / PLK4

serine/threonine-protein kinase PLK4 isoform 1; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase PLK4; polo like kinase 4; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase Sak

PLK4

Sak; STK18

PLK4; PLK4; SAK; STK18; MCCRP2; SAK; STK18; PLK-4

PLK4_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Dog, Cow

970

ATCIGEKIEDFKVGN

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 110kDa band observed in Human Colon lysates (calculated MW of 109kDa according to NP_055079.3). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence ATCIGEKIEDFKVGN, from the N Terminus of the protein sequence according to NP_055079.3. Epitope: N Terminus

121114283

NP_055079.3

NM_014264.4

104,636 Da

AURKA Activation By TPX2 Pathway (1383018); Anchoring Of The Basal Body To The Plasma Membrane Pathway (1268847); Assembly Of The Primary Cilium Pathway (1268846); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Centrosome Maturation Pathway (1269805); FoxO Signaling Pathway (921162); G2/M Transition Pathway (1269799); Loss Of Nlp From Mitotic Centrosomes Pathway (1269809); Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway (1269808)

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

PLK4: a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec. Protein type: EC 2.7.11.21; Protein kinase, Other; Nucleolus; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family. Chromosomal Location of Human Ortholog: 4q28. Cellular Component: centriole; centrosome; cleavage furrow; cytosol; nucleolus; XY body. Molecular Function: ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity. Biological Process: centriole replication; G2/M transition of mitotic cell cycle; positive regulation of centriole replication; protein amino acid phosphorylation. Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2

0.1 mg

300 USD