antibody

Goat anti-KLK2 Antibody

MBS420955

0.1 mg

300 USD

polyclonal

goat

nonconjugated

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-KLK2 Antibody

KLK2

KLK2; kallikrein-related peptidase 2; KLK2A2; MGC12201; hK2; glandular kallikrein 2; kallikrein 2, prostatic; KLK2 antibody; kallikrein-related peptidase 2 antibody; KLK2A2 antibody; MGC12201 antibody; hK2 antibody; glandular kallikrein 2 antibody; kallikrein 2; prostatic antibody

kallikrein-2 isoform 1 preproprotein; Kallikrein-2; kallikrein-2; kallikrein related peptidase 2; Glandular kallikrein-1; hGK-1; Tissue kallikrein-2

KLK2

KLK2; KLK2; hK2; hGK-1; KLK2A2; hGK-1

KLK2_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human

261

KHQSLRPDEDSSHD

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Prostate shows vesicular staining in the secretory cells. Recommended concentration, 2.5-3.8ug/ml. Western Blot: Approx 22kDa band observed in Human Prostate lysates (calculated MW of 24.7kDa according to NP_001002231.1). Recommended concentration: 0.1-0.3ug/ml.

Immunogen: Peptide with sequence C-KHQSLRPDEDSSHD, from the internal region of the protein sequence according to NP_005542.1; NP_001002231.1. Epitope: Internal region

Note: This antibody is expected to recognize both reported isoforms (NP_005542.1; NP_001002231.1).

5031829

NP_005542.1

NM_005551.4

17,301 Da

Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway (1269513); Activation Of Matrix Metalloproteinases Pathway (1270258); Coregulation Of Androgen Receptor Activity Pathway (138085); Degradation Of The Extracellular Matrix Pathway (1270257); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Extracellular Matrix Organization Pathway (1270244); Metabolism Of Proteins Pathway (1268677); Prostate Cancer Pathway (755440); RHO GTPase Effectors Pathway (1269509)

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.35; Protease. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region. Molecular Function: serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; proteolysis

0.1 mg

300 USD