antibody

Goat anti-Prealbumin/Transthyretin Antibody

MBS420933

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

ELISA, enzyme immunoassay

Antibody

Goat anti-Prealbumin/Transthyretin Antibody

Prealbumin/Transthyretin

Goat Anti-prealbumin / transthyretin (aa62-74) Antibody; TTR; transthyretin (prealbumin, amyloidosis type I); HGNC: 12405; HsT2651; PALB; TBPA; prealbumin; transthyretin; TTR antibody; transthyretin (prealbumin; amyloidosis type I) antibody; HGNC: 12405 antibody; HsT2651 antibody; PALB antibody; TBPA antibody; prealbumin antibody; transthyretin antibody; Prealbumin; Transthyretin; Prealbumin / Transthyretin

transthyretin; Transthyretin; transthyretin; transthyretin; ATTR; Prealbumin; TBPA

TTR

TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB

TTHY_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

147

YKVEIDTKSYWK

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 1000. Western Blot: Preliminary experiments gave an approx 20-22kDa band in Human Heart, Kidney, Liver, Lung, Placenta and Testis lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 15.9kDa according to NP_000362.1. The 20-22kDa band was successfully blocked by incubation with the immunizing peptide. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant TTR captured by a rabbit antibody. Recommended reporter concentration: 5-10ug/ml.

Immunogen: Peptide with sequence C-YKVEIDTKSYWK, from the internal region of the protein sequence according to NP_000362.1. Epitope: Internal region

4507725

NP_000362.1

NM_000371.3

15,887 Da

Amyloid Fiber Formation Pathway (1269169); Disease Pathway (1268854); Diseases Associated With Visual Transduction Pathway (1268929); Diseases Of Signal Transduction Pathway (1268855); Extracellular Matrix Organization Pathway (1270244); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Metabolism Pathway (1269956); Metabolism Of Fat-soluble Vitamins Pathway (1339147); Metabolism Of Proteins Pathway (1268677); Metabolism Of Vitamins And Cofactors Pathway (1270144)

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: cytoplasm; extracellular region; extracellular space; protein complex. Molecular Function: hormone activity; hormone binding; identical protein binding; protein binding; protein heterodimerization activity. Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; retinoid metabolic process; retinol metabolic process; transport. Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic

0.1 mg

300 USD