catalog number :
MBS420924
products full name :
Goat anti-SOCS5 Antibody
products short name :
SOCS5
products name syn :
SOCS5; suppressor of cytokine signaling 5; CIS6; CISH6; KIAA0671; cytokine-inducible SH2 protein 6; Cish5; SOCS-5; SOCS5; suppressor of cytokine signaling 5; CIS6; CISH6; KIAA0671; cytokine-inducible SH2 protein 6; Cish5; SOCS-5
other names :
suppressor of cytokine signaling 5; Suppressor of cytokine signaling 5; suppressor of cytokine signaling 5; CIS-6; cytokine-inducible SH2 protein 6; cytokine-inducible SH2-containing protein 5; suppressor of cytokine signaling 5; Cytokine-inducible SH2 protein 6; CIS-6; Cytokine-inducible SH2-containing protein 5
products gene name :
SOCS5
other gene names :
SOCS5; SOCS5; CIS6; CISH6; Cish5; SOCS-5; CIS6; CISH5; CISH6; KIAA0671; SOCS-5; CIS-6
uniprot entry name :
SOCS5_HUMAN
reactivity :
Human, Mouse, Rat, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 65kDa band observed in lysates of cell line Molt4 (calculated MW of 61.2kDa according to NP_054730.1). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence DKVGKMWNNFK-C, from the N Terminus of the protein sequence according to NP_054730.1. Corresponding Immunizing Peptide: Catalog #MBS426817
other info2 :
Important Note: Both reported variants represent identical protein: NP_054730.1 and NP_659198.1.
products references :
Kuhad A, Bishnoi M, Tiwari V, Chopra K.; Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits.; Pharmacol Biochem Behav. 2009 Apr; 92(2):251-9.; Pubmed 19138703
ncbi acc num :
NP_054730.1
ncbi gb acc num :
NM_014011.4
ncbi mol weight :
61,246 Da
ncbi pathways :
ECS Complex Pathway 413455!!ECS Complex Pathway 468394!!IL-4 Signaling Pathway 198760!!IL4-mediated Signaling Events Pathway 137933!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!Kit Receptor Signaling Pathway 198826!!Prolactin Signaling Pathway 814182!!Prolactin Signaling Pathway 814248
ncbi summary :
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]