antibody

Goat anti-Cdc42-binding kinase alpha Antibody

MBS420908

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-Cdc42-binding kinase alpha Antibody

Cdc42-binding kinase alpha

CDC42BPA; MRCK; MRCKA; PK428; FLJ23347; KIAA0451; CDC42 binding protein kinase alpha (DMPK-like); ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; DKFZp686L1738; CDC42 binding protein kinase beta; CDC42BPA; MRCK; MRCKA; PK428; FLJ23347; KIAA0451; CDC42 binding protein kinase alpha (DMPK-like); ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; DKFZp686L1738; CDC42 binding protein kinase beta

serine/threonine-protein kinase MRCK alpha isoform A; Serine/threonine-protein kinase MRCK alpha; serine/threonine-protein kinase MRCK alpha; CDC42BPA; DMPK-like alpha; ser-thr protein kinase PK428; CDC42 binidng protein kinase beta; myotonic dystrophy protein kinase-like alpha; CDC42-binding protein kinase alpha (DMPK-like); myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; ser-thr protein kinase related to the myotonic dystrophy protein kinase; CDC42 binding protein kinase alpha (DMPK-like); CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha

CDC42BPA

CDC42BPA; CDC42BPA; MRCK; MRCKA; PK428; MRCK alpha; Myotonic dystrophy protein kinase-like alpha

MRCKA_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Cow

1638

SGEVRLRQLEQFI

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry: In paraffin embedded Human Cerebellum shows cytoplasm staining in purkinje cells. Recommended concentration, 3-6ug/ml. Western Blot: Preliminary experiments gave an approx 30kDa and 40kDa bands in Human Pancreas lysates at 1ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated sizes of 186kDa according to NP_055641.3 and 196kDa according to NP_003598.2. Peptide ELISA: antibody detection limit dilution 1:16000.

Epitope: N Terminus. Immunogen: Peptide with sequence SGEVRLRQLEQFI-C, from the N Terminus of the protein sequence according to NP_055641.3; NP_003598.2. Corresponding Immunizing Peptide: Catalog #MBS426974

Important Note: This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).

30089960

NP_055641.3

NM_014826.4

202,812 Da

CDC42 Signaling Events Pathway 137994

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD