catalog number :
MBS420901
products full name :
Goat anti-Cathepsin K Antibody
products short name :
Cathepsin K
products name syn :
CTSK; cathepsin K; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; cathepsin K (pycnodysostosis); cathepsin O1; cathepsin O2; cathepsin X; CTSK; cathepsin K; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; cathepsin K (pycnodysostosis); cathepsin O1; cathepsin O2; cathepsin X
other names :
cathepsin K preproprotein; Cathepsin K; cathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2; cathepsin K; Cathepsin O; Cathepsin O2; Cathepsin X
products gene name :
CTSK
other gene names :
CTSK; CTSK; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; CTSO; CTSO2
uniprot entry name :
CATK_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 36kDa band observed in Human Lung and Human Ovary lysates (calculated MW of 37.0kDa according to NP_000387.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000. Enzyme immunoassay: Anonymous customer reported successful use in quantitative ELISA using the immunizing peptide for calibration,
other info1 :
Epitope: Internal Region (Near N Terminus). Immunogen: Peptide with sequence C-KTHRKQYNNKVDE, from the internal region (near N Terminus) of the protein sequence according to NP_000387.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425026
ncbi acc num :
NP_000387.1
ncbi gb acc num :
NM_000396.3
ncbi mol weight :
36,966 Da
ncbi pathways :
Activation Of Matrix Metalloproteinases Pathway 576264!!Adaptive Immune System Pathway 366160!!Collagen Degradation Pathway 730309!!Degradation Of The Extracellular Matrix Pathway 576263!!Extracellular Matrix Organization Pathway 576262!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Lysosome Pathway 99052!!Lysosome Pathway 96865!!MHC Class II Antigen Presentation Pathway 645290
ncbi summary :
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]