antibody

Goat anti-ACVR1 Antibody

MBS420900

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-ACVR1 Antibody

ACVR1

ACVR1; activin A receptor; type I; ACTRI; ACVRLK2; ALK2; FOP; SKR1; activin A receptor; type II-like kinase 2; activin A type I receptor; hydroxyalkyl-protein kinase; activin A receptor, type I; ACTRI; ACVRLK2; ALK2; FOP; SKR1; activin A receptor, type II-like kinase 2; activin A type I receptor; hydroxyalkyl-protein kinase

activin receptor type-1; Activin receptor type-1; activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; activin A receptor, type I; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I

ACVR1

ACVR1; ACVR1; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I

ACVR1_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog

509

RKFKRRNQERLNPRD

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Testis shows preferential staining of cytoplasm in primary spermatocytes. Recommended concentration, 4-6ug/ml. Western Blot: Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence according to NP_001096.1.

Corresponding Immunizing Peptide: Catalog #MBS426392

4501895

NP_001096.1

NM_001105.4

57,153 Da

ALK1 Pathway 137985!!ALK1 Signaling Events Pathway 137968!!ALK2 Signaling Events Pathway 137983!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Signaling Pathways Regulating Pluripotency Of Stem Cells 1026136!!Signaling Pathways Regulating Pluripotency Of Stem Cells 1033502!!TGF-beta Signaling Pathway 83064!!TGF-beta Signaling Pathway 475

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD