Goat anti-Serotonin receptor 3A/HTR3A Antibody | MyBioSource MBS420895 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Serotonin receptor 3A/HTR3A Antibody

catalog :

MBS420895

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420895

products type :

Antibody

products full name :

Goat anti-Serotonin receptor 3A/HTR3A Antibody

products short name :

Serotonin receptor 3A/HTR3A

products name syn :

HTR3A; serotonin receptor; 5-hydroxytryptamine (serotonin) receptor 3A; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3; 5-hydroxytryptamine (serotonin) receptor-3; 5HT3 serotonin receptor; Serotonin-gated ion channel receptor; truncated receptor, containing only 3 t; HTR3A antibody; serotonin receptor antibody; 5-hydroxytryptamine (serotonin) receptor 3A antibody; 5-HT-3 antibody; 5-HT3A antibody; 5-HT3R antibody; 5HT3R antibody; HTR3 antibody; 5-hydroxytryptamine (serotonin) receptor-3 antibody; 5HT3 serotonin receptor antibody; Serotonin-gated ion channel receptor antibody; truncated receptor; containing only 3 transmembrane domains antibody; Serotonin receptor 3A; Serotonin receptor 3A / HTR3A

other names :

5-hydroxytryptamine receptor 3A isoform a; 5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor

products gene name :

HTR3A

other gene names :

HTR3A; HTR3A; HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R

uniprot entry name :

5HT3A_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Rat; Expected from sequence similarity: Human

sequence length :

516

sequence :

GPQDFEKSPRDR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Immunocytochemsitry/Immunofluorescence: This antibody has been successfully used in ICC/IF for rat neurons as described in the following paper: Lu et al, Gastroenterology.2009 Sep;137(3): 1040-50.; PMID: 19344720.

other info1 :

Immunogen: Peptide with sequence C-GPQDFEKSPRDR, from the internal region of the protein sequence according to NP_998786.2; NP_000860.2; NP_001155244.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise all three reported isoforms (NP_998786.2; NP_000860.2; NP_001155244.1).

ncbi gi num :

253735697

ncbi acc num :

NP_998786.2

ncbi gb acc num :

NM_213621.3

ncbi mol weight :

59,002 Da

ncbi pathways :

Ion Channel Transport Pathway (1269950); Ligand-gated Ion Channel Transport Pathway (1269952); SIDS Susceptibility Pathways (198901); Serotonergic Synapse Pathway (525336); Taste Transduction Pathway (83088); Taste Transduction Pathway (499); Transmembrane Transport Of Small Molecules Pathway (1269903)

ncbi summary :

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ion channel; Channel, ligand-gated; Channel, cation; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q23.1. Cellular Component: axon; cell junction; cell soma; cytoplasm; integral to plasma membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane. Molecular Function: acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; receptor activity; serotonin binding; serotonin receptor activity; serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity. Biological Process: digestion; response to cocaine; response to ethanol; serotonin receptor signaling pathway; synaptic transmission; synaptic transmission, cholinergic; transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage