antibody

Goat anti-RXR gamma Antibody

MBS420893

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-RXR gamma Antibody

RXR gamma

RXRG; RXRC; NR2B3; retinoid X receptor, gamma; RXRG antibody; RXRC antibody; NR2B3 antibody; retinoid X receptor; gamma antibody; RXR gamma

retinoic acid receptor RXR-gamma isoform a; Retinoic acid receptor RXR-gamma; retinoic acid receptor RXR-gamma; retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma

RXRG

RXR gamma

RXRG; RXRG; RXRC; NR2B3; NR2B3

RXRG_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

463

RQRSRERAESEAEC

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 65kDa band observed in lysates of cell line HeLa (calculated MW of 50.9kDa according to NP_008848.1). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence RQRSRERAESEAEC, from the internal region of the protein sequence according to NP_008848.1. Epitope: Internal region

Note: This antibody is expected to recognise an epitope corresponding to aa 213-226 of human RXR gamma protein (hinge region) and does not cross-react with either RXR alpha or beta.

5902068

NP_008848.1

NM_006917.4

50,871 Da

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); PPAR Signaling Pathway (83042)

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 1q22-q23. Cellular Component: nucleoplasm. Molecular Function: protein binding; retinoid-X receptor activity; steroid hormone receptor activity; zinc ion binding. Biological Process: protein homotetramerization; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter

0.1 mg

300 USD