catalog number :
MBS420881
products full name :
Goat anti-T-cell differentiation protein Antibody
products short name :
T-cell differentiation protein
products name syn :
MAL; mal; T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein; MAL; mal, T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein
other names :
myelin and lymphocyte protein isoform a; Myelin and lymphocyte protein; myelin and lymphocyte protein; T-lymphocyte maturation-associated protein; mal, T-cell differentiation protein; T-lymphocyte maturation-associated protein
other gene names :
MAL; MAL
uniprot entry name :
MAL_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Thymus and Thyroid Gland lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 16.7kDa according to NP_002362.1. The 35kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:4000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-QDGFTYRHYHEN, from the internal region of the protein sequence according to NP_002362.1; NP_071884.1. Corresponding Immunizing Peptide: Catalog #MBS425754
other info2 :
Important Note: This antibody is expected to recognise isoform a (NP_002362.1) and isoform c (NP_071884.1).
ncbi acc num :
NP_002362.1
ncbi gb acc num :
NM_002371.3
ncbi mol weight :
5,989 Da
ncbi summary :
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]