Goat anti-THRA Antibody | MyBioSource MBS420860 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-THRA Antibody

catalog :

MBS420860

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420860

products type :

Antibody

products full name :

Goat anti-THRA Antibody

products short name :

THRA

products name syn :

THRA; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); AR7; EAR7; ERB-T-1; ERBA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; c-ERBA-1; ERBA-related 7; avian erythroblastic leukemia viral (v-erb-a) onc; THRA antibody; thyroid hormone receptor; alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog; avian) antibody; AR7 antibody; EAR7 antibody; ERB-T-1 antibody; ERBA antibody; ERBA1 antibody; MGC000261 antibody; MGC43240 antibody; NR1A1 antibody; THRA1 antibody; THRA2 antibody; c-ERBA-1 antibody; ERBA-related 7 antibody; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog antibody; thyroid hormone receptor; alpha antibody; triiodothyronine receptor antibody

other names :

thyroid hormone receptor alpha isoform 1; Thyroid hormone receptor alpha; thyroid hormone receptor alpha; thyroid hormone receptor, alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha

products gene name :

THRA

other gene names :

THRA; THRA; AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1; EAR7; ERBA1; NR1A1; THRA1; THRA2; EAR-7

uniprot entry name :

THA_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

410

sequence :

KEEMIRSLQQRP

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60+50kDa bands observed in Human Bone Marrow lysates (calculated MW of 54.8kDa according to NP_003241.2 and of 46.8kDa according to NP_955366.1). Recommended concentration: 0.5-1,5ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KEEMIRSLQQRP, from the internal region of the protein sequence according to NP_955366.1; NP_003241.2. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both reported isoforms (NP_955366.1; NP_003241.2). This antibody is not expected to cross-react to THRB.

ncbi gi num :

40806160

ncbi acc num :

NP_955366.1

ncbi gb acc num :

NM_199334.3

ncbi mol weight :

50,465 Da

ncbi pathways :

Endochondral Ossification Pathway (198812); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); Thyroid Hormone Signaling Pathway (946598)

ncbi summary :

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described. Protein type: Nuclear receptor; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus. Molecular Function: chromatin DNA binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; steroid hormone receptor activity; TATA-binding protein binding; thyroid hormone receptor activity; transcription factor activity; transcription factor binding; zinc ion binding. Biological Process: adrenal gland development; brain development; cartilage condensation; cytoplasmic sequestering of transcription factor; embryonic organ development; erythrocyte differentiation; female courtship behavior; gut development; hormone-mediated signaling; intracellular receptor-mediated signaling pathway; kidney development; learning and/or memory; liver development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of transcriptional preinitiation complex assembly; ossification; positive regulation of female receptivity; positive regulation of transcription from RNA polymerase II promoter; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptosis; regulation of transcription from RNA polymerase II promoter; response to cold; response to drug; response to nutrient levels; steroid hormone mediated signaling; thyroid gland development; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter. Disease: Hypothyroidism, Congenital, Nongoitrous, 6

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage