Goat anti-NEDD9 Antibody | MyBioSource MBS420844 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NEDD9 Antibody

catalog :

MBS420844

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420844

products type :

Antibody

products full name :

Goat anti-NEDD9 Antibody

products short name :

NEDD9

products name syn :

NEDD9; neural precursor cell expressed, developmentally down-regulated 9; CAS-L; CASL; HEF1; dJ49G10.2; dJ761I2.1; Crk-associated substrate related; cas-like docking dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1 (enhancer of filamentation (HEF; NEDD9 antibody; neural precursor cell expressed; developmentally down-regulated 9 antibody; CAS-L antibody; CASL antibody; HEF1 antibody; dJ49G10.2 antibody; dJ761I2.1 antibody; Crk-associated substrate related antibody; cas-like docking dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)) antibody; dJ761I2.1 (enhancer of filamentation (HEF1)) antibody; enhancer of filamentation 1 antibody

other names :

enhancer of filamentation 1 isoform 1; Enhancer of filamentation 1; enhancer of filamentation 1; neural precursor cell expressed, developmentally down-regulated 9; CRK-associated substrate-related protein; CAS-L; CasL

products gene name :

NEDD9

other gene names :

NEDD9; NEDD9; CAS2; CASL; HEF1; CAS-L; CASS2; CASL; CASS2; hEF1; CAS-L; CasL; NEDD-9

uniprot entry name :

CASL_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

834

sequence :

NKPQNKCDDLDR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 100kDa band observed in Human Kidney, Lung and Placenta lysates (calculated MW of 92.9kDa according to NP_006394.1). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence NKPQNKCDDLDR, from the internal region of the protein sequence according to NP_006394.1; NP_892011.2. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise isoform 1 (NP_006394.1) only.

ncbi gi num :

5453680

ncbi acc num :

NP_006394.1

ncbi gb acc num :

NM_006403.3

ncbi mol weight :

92,885 Da

ncbi pathways :

B Cell Receptor Signaling Pathway (198909)

ncbi summary :

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

uniprot summary :

Cas-L: a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 6p24.2. Cellular Component: cell cortex; cytoplasm; focal adhesion; Golgi apparatus; lamellipodium; nucleus; spindle; spindle pole. Molecular Function: protein binding. Biological Process: actin filament bundle formation; cell adhesion; cell division; cytoskeleton organization and biogenesis; integrin-mediated signaling pathway; mitosis; regulation of growth; signal transduction

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage