catalog number :
MBS420824
products full name :
Goat anti-SH2-B / SH2B1 (isoform2) Antibody
products short name :
SH2-B/SH2B1
products name syn :
SH2B1; SH2B; SH2-B; DKFZP547G1110; SH2-B homolog; SH2-B alpha signaling protein; SH2-B gamma signaling protein; likely ortholog of mouse SH2 domain-containing putative adapter SH2-B; SH2B adaptor protein 1; DKFZp547G1110; FLJ30542; KIAA1299; PSM; SH2 domain-containing protein 1B; SH2-B signaling protein; pro-rich; PH and SH2 domain-containing signaling mediator; SH2B1; SH2B; SH2-B; DKFZP547G1110; SH2-B homolog; SH2-B alpha signaling protein; SH2-B gamma signaling protein; likely ortholog of mouse SH2 domain-containing putative adapter SH2-B; SH2B adaptor protein 1; DKFZp547G1110; FLJ30542; KIAA1299; PSM; SH2 domain-containing protein 1B; SH2-B signaling protein; pro-rich, PH and SH2 domain-containing signaling mediator
other names :
SH2B adapter protein 1 isoform 2; SH2B adapter protein 1; SH2B adapter protein 1; SH2-B signaling protein; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; pro-rich, PH and SH2 domain-containing signaling mediator; SH2B adaptor protein 1; Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B
products gene name :
SH2B1
other gene names :
SH2B1; SH2B1; PSM; SH2B; KIAA1299; SH2B; PSM
uniprot entry name :
SH2B1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 45-48kDa band in human heart lysate at 1ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the predicted size of 70.6kDa according to NP_056318.1. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence PFGASDCVTDHLP, from the C Terminus of the protein sequence according to NP_056318.2. Corresponding Immunizing Peptide: Catalog #MBS425978
other info2 :
Important Note: This antibody is expected to recognise isoform 2 (NP_056318.2) only. Reported variants represent identical protein (NP_001139268.1; NP_056318.2; NP_001139284.1).
ncbi acc num :
NP_056318.2
ncbi gb acc num :
NM_015503.2
ncbi mol weight :
72,188 Da
ncbi pathways :
BDNF Signaling Pathway 712093!!Cytokine Signaling In Immune System Pathway 366171!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!Growth Hormone Receptor Signaling Pathway 477128!!Hemostasis Pathway 106028!!Immune System Pathway 106386!!Leptin Signaling Pathway 672456!!Neurotrophin Signaling Pathway 101143!!Neurotrophin Signaling Pathway 100064!!Nuclear Signaling By ERBB4 Pathway 530744
ncbi summary :
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]