Goat anti-PTBP1 / PTB Antibody | MyBioSource MBS420820 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-PTBP1 / PTB Antibody

catalog :

MBS420820

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420820

products type :

Antibody

products full name :

Goat anti-PTBP1 / PTB Antibody

products short name :

PTBP1/PTB

products name syn :

PTBP1; PTB; polypyrimidine tract binding protein 1; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; HNRNPI; RNA binding protein; heterogeneous nuclear ribonucleoprotein polypeptide I; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); HNRNP-I; MGC10830; MGC8461; RNA-binding protein; heterogeneous nuclear ribonucleoprotein I; PTBP1; PTB; polypyrimidine tract binding protein 1; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; HNRNPI; RNA binding protein; heterogeneous nuclear ribonucleoprotein polypeptide I; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); HNRNP-I; MGC10830; MGC8461; RNA-binding protein; heterogeneous nuclear ribonucleoprotein I

other names :

polypyrimidine tract-binding protein 1 isoform a; Polypyrimidine tract-binding protein 1; polypyrimidine tract-binding protein 1; hnRNP I; RNA-binding protein; 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; hnRNP I

products gene name :

PTBP1

other gene names :

PTBP1; PTBP1; PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I; PTB; PTB; hnRNP I

uniprot entry name :

PTBP1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

557

sequence :

DGIVPDIAVGTKR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Immunohistochemistry: In paraffin embedded Human Skin shows nuclear staining of keratinocytes. Data obtained from a previous batch (from different goat). Recommended concentration, 5-10ug/ml. Western Blot: Approx 55kDa band observed in Human Liver and Ovary lysates, and 60kDa band observed in nuclear lysates of cell lines HeLa, HepG2, Jurkat and HEK293 (calculated MW of 57.2kDa according to NP_114368.1). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

other info1 :

Epitope: N Terminus. Immunogen: Peptide with sequence DGIVPDIAVGTKR-C, from the N Terminus of the protein sequence according to NP_002810.1; NP_114367.1; NP_114368.1; NP_787041.1. Corresponding Immunizing Peptide: Catalog #MBS426220

other info2 :

Important Note: This antibody is expected to recognise all 4 reported isoforms (represented by NP_002810.1; NP_114367.1; NP_114368.1; NP_787041.1).

ncbi gi num :

4506243

ncbi acc num :

NP_002810.1

ncbi gb acc num :

NM_002819.4

ncbi mol weight :

59,633 Da

ncbi pathways :

Gene Expression Pathway 105937!!Processing Of Capped Intron-Containing Pre-mRNA Pathway 160950!!MRNA Splicing Pathway 105951!!MRNA Splicing - Major Pathway 105952!!MRNA Processing Pathway 198843

ncbi summary :

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage